PMID: 7333702Dec 1, 1981Paper

Estrogen receptor quantitation and staging as complementary prognostic indicators in breast cancer: a study of 583 patients

International Journal of Cancer. Journal International Du Cancer
W GodolphinJ J Spinelli

Abstract

Estrogen receptor (ER) quantity was measured at the time of primary diagnosis on 583 patients with breast cancer seen at the major treatment centre in British Columbia between 1975 and 1979. Survival rates (overall, recurrence-free and post-recurrence) were assessed relative to ER concentration, staging, menopausal status, age, differentiation, and therapy. A linear trend in increased survival was demonstrable through variations in ER concentration from less than 1 to greater than 260 fmoles/mg cytosol protein. This trend was highly significant and remained after adjustment for stage, menopausal status, and age, and was seen for all groups of patients except those with metastatic disease. The association of high ER concentration with increased recurrence-free survival was not due to differing responses to adjuvant therapy, but the trend in post-recurrence survival was only significant in patients who had received hormonal therapy. Survival was as strongly associated with receptor concentration as with staging, and these two factors were almost completely independent. A proportional hazards model was fitted to produce predictions of survival, and showed that TNM stage III patients with high ER concentrations have a better surviv...Continue Reading

References

May 12, 1979·Lancet·T CookeK Griffiths
Jan 25, 1975·British Medical Journal·G LeclercqW H Mattheiem
Nov 1, 1979·The New England Journal of Medicine·E R DeSombreM B Lipsett
May 1, 1973·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Jan 1, 1980·Journal of Immunoassay·W Godolphin, B Jacobson
Feb 1, 1981·Cancer·N A SamaanR Martin
Oct 15, 1980·International Journal of Cancer. Journal International Du Cancer·H WesterbergA Wallgren

❮ Previous
Next ❯

Citations

Jan 1, 1989·Acta neurochirurgica·N GibelliG Robustelli della Cuna
Jan 1, 1985·Breast Cancer Research and Treatment·H O AdamiJ Sällström
Jan 1, 1983·Breast Cancer Research and Treatment·S M ThorpeB B Rasmussen
Jan 1, 1986·Breast Cancer Research and Treatment·S E TonikH H Sussman
Jan 1, 1986·Breast Cancer Research and Treatment·R J PegoraroS M Joubert
Jan 1, 1982·Breast Cancer Research and Treatment·S ThoresenF Hartveit
Jan 1, 1983·Breast Cancer Research and Treatment·S SaezB Asselain
Feb 1, 1989·European Journal of Cancer & Clinical Oncology·L L Shek, W Godolphin
Oct 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J W ChapmanK I Pritchard
May 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·J A ChapmanD J Sutherland
Mar 1, 1996·The Journal of Steroid Biochemistry and Molecular Biology·J W ChapmanK I Pritchard
Dec 10, 1997·American Journal of Clinical Oncology·P S HupperetsG H Blijham
Nov 1, 1990·Journal of Neurosurgery·P PaolettiG Robustelli della Cuna
Jan 1, 1988·Critical Reviews in Clinical Laboratory Sciences·V C JordanW V Welshons
Apr 17, 2010·Cancer Investigation·Hongyan QuHaifeng Liu
Jun 1, 1988·Pathology, Research and Practice·F WrbaJ Spona
Apr 1, 1993·Cancer Treatment Reviews·E Lønning
Mar 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T TokoY Yamada
Nov 1, 1987·The British Journal of Surgery·R A HawkinsA P Forrest
Apr 1, 1988·Journal of Surgical Oncology·S RydénA Norgren
Jun 1, 2013·International Journal of Surgery·Tomás CortadellasAntonio Gil
Feb 24, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·T CortadellasA Gil-Moreno
Oct 24, 2006·Breast Cancer Research : BCR·Greg FinakMorag Park
Sep 15, 2001·Applied Immunohistochemistry & Molecular Morphology : AIMM·M Ferrero-PoüsF Spyratos
Mar 31, 2007·Annals of Epidemiology·Sharon K SagivMarilie D Gammon
May 1, 1991·The British Journal of Surgery·Z Rayter

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.