PMID: 9554526Apr 29, 1998Paper

Estrogen-receptor-related protein p29 in primary nonsmall cell lung carcinoma: pathologic and prognostic correlations

Cancer
S O VargasD L Weaver

Abstract

Estrogen-dependent intracellular processes are important in the growth regulation of normal tissue and may play a role in the regulation of malignancies. Utilization of estrogen receptor assays in breast carcinoma is well established, but the role of such evaluation in other cancers largely is unknown. In this study, immunohistochemical expression of estrogen receptor (ER) and the ER-related protein p29 was correlated with survival of patients with nonsmall cell carcinoma of the lung. All patients with a tissue diagnosis of primary nonsmall cell bronchogenic carcinoma diagnosed over a 6-year period at the Medical Center Hospital of Vermont were reviewed. Assays for p29 and ER using a streptavidin-biotin immunoperoxidase method were performed on each tumor. Results were correlated with clinical data, including survival. Of 111 tumors examined, 109 (98%) were positive for p29 whereas none of the tumors reacted with ER (ER1D5). The relation between p29 expression and survival time was different for men and women. A statistically significant negative relation for women was observed; this relation was most pronounced in patients with Stage I and II tumors. A positive but not statistically significant relation was observed for men. T...Continue Reading

Citations

Feb 5, 2002·Annual Review of Physiology·Sabine Zochbauer-MullerJohn D Minna
Oct 22, 2004·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Patricia A Tabloski
Nov 22, 2000·Pathology, Research and Practice·H UozakiR Machinami
Aug 24, 2005·Gender Medicine·José M ChatkinJose A L F Pinto
Feb 16, 2002·The Annals of Thoracic Surgery·David J DabbsJan F Silverman
Dec 29, 1999·The Journal of Thoracic and Cardiovascular Surgery·M de PerrotA Spiliopoulos
Mar 17, 2006·Applied Immunohistochemistry & Molecular Morphology : AIMM·Sean K LauLawrence M Weiss

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