Estrogen receptor subtype-specific effects on markers of bone homeostasis

Molecular and Cellular Endocrinology
T HertrampfPatrick Diel

Abstract

To further elucidate the processes involved in the physiology of bone-protection by estrogens, ovariectomized (OVX) rats were treated subcutaneously with 17beta-estradiol (E(2)), the ERalpha-specific agonist (16alpha-LE2) and the ERbeta-specific agonist (8beta-VE2). OVX and intact animals served as controls. Biomarkers of bone-formation (osteocalcin (OC), osteopontin (OPN)) and bone-resorption (telopeptides of collagen type I (CTx), pyridinoline cross-links (Pyd)) were quantified. Bone mineral density was measured by computed tomography. OVX-induced bone loss could be antagonized by subcutaneous administration of 17beta-estradiol and 16alpha-LE2. Serum levels of CTx, OC and OPN were significantly elevated in OVX compared to intact animals and reduced by 17beta-estradiol and 16alpha-LE2. Treatment of OVX rats with 8beta-VE2 did not affect bone mineral density (BMD) or bone-marker serum levels. Taken together, the complex expression pattern of bone-markers in OVX rats following subcutaneous administration of ER subtype-specific agonists indicates that 17beta-estradiol exerts its bone-protective effects by modulating the activity of osteoclasts and osteoblasts via ERalpha.

References

Dec 1, 1991·Bone and Mineral·D N Kalu
Jan 1, 1989·Connective Tissue Research·W T Butler
Feb 5, 2000·Clinical Science·R Bland
Jun 30, 2000·Human Reproduction Update·J L Díez
Oct 6, 2000·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·J SodekM D McKee
Nov 9, 2000·Proceedings of the National Academy of Sciences of the United States of America·P A HeineP S Cooke
Nov 3, 2001·The Journal of Endocrinology·M K LindbergC Ohlsson
Jan 5, 2002·Current Opinion in Pharmacology·S O Mueller, K S Korach
Aug 15, 2002·The Journal of Endocrinology·M K LindbergC Ohlsson
Jul 25, 2003·Nature·Karla LeeLance Lanyon
Sep 11, 2003·Veterinary Clinical Pathology·M J Allen
Sep 13, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mikihiko MorinobuMasaki Noda
Mar 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Christa Hegele-HartungKarl-Heinrich Fritzemeier
Oct 20, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Farhan A SyedSundeep Khosla
Jun 27, 2006·Journal of Dental Research·U H Lerner
Sep 5, 2006·Clinical calcium·Toshio Matsumoto
Nov 23, 2006·Arquivos brasileiros de endocrinologia e metabologia·Lorraine A Fitzpatrick
Dec 19, 2006·The International Journal of Biochemistry & Cell Biology·J M BlairC R Dunstan
Feb 20, 2007·Annals of the New York Academy of Sciences·Dimitrios J Hadjidakis, Ioannis I Androulakis
Dec 11, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·V Craig Jordan

❮ Previous
Next ❯

Citations

Jul 28, 2013·Sports Medicine·Martina Velders, Patrick Diel
Nov 21, 2009·Joint, Bone, Spine : Revue Du Rhumatisme·Pascal Guggenbuhl
May 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Yu-Ling HuangWen-Fei Chiou
Jul 6, 2014·Journal of Osteoporosis·Babita BalakrishnanMadhavi Manohar Indap
Jul 7, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Nagla A El-ShitanyKarema El-Desoky
Oct 4, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H-L ChenC-M Chen
Sep 22, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Zhiguo ZhangDahong Ju
Sep 18, 2014·Brazilian Oral Research·Tábata de Mello TeraMaria Aparecida Neves Jardini
May 5, 2017·American Journal of Physiology. Cell Physiology·Zhiqin DengLiwei Wang
Oct 12, 2017·Frontiers in Chemistry·Konstantinos M KasiotisSerkos A Haroutounian
May 28, 2020·International Journal of Molecular Sciences·Elena S GardiniUlrike Ehlert
Oct 18, 2013·Experimental Biology and Medicine·Ebru OrsalSeda Ozaltin
Oct 26, 2012·Menopause : the Journal of the North American Menopause Society·Zhi-Guo ZhangDa-Hong Ju

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.