Estrogen receptors and endothelium

Arteriosclerosis, Thrombosis, and Vascular Biology
Jean-François ArnalPierre Gourdy

Abstract

Estrogens, and in particular 17beta-estradiol (E2), play a pivotal role in sexual development and reproduction and are also implicated in a large number of physiological processes, including the cardiovascular system. Both acetylcholine-induced and flow-dependent vasodilation are preserved or potentiated by estrogen treatment in both animal models and humans. Indeed, E2 increases the endothelial production of nitric oxide and prostacyclin and prevents early atheroma through endothelial-mediated mechanisms. Furthermore, whereas it prevents endothelial activation, E2 potentiates the ability of several subpopulations of the circulating or resident immune cells to produce proinflammatory cytokines. The balance between these 2 actions could determine the final effect in a given pathophysiological process. E2 also promotes endothelial healing, as well as angiogenesis. Estrogen actions are essentially mediated by 2 molecular targets: estrogen receptor-alpha (ERalpha) and ERbeta. The analysis of mouse models targeted for ERalpha or ERbeta demonstrated a prominent role of ERalpha in vascular biology. ERalpha directly modulates transcription of target genes through 2 activation functions (AFs), AF-1 and AF-2. Interestingly, an AF-1-defic...Continue Reading

References

Sep 1, 1978·Science·P Colburn, V Buonassisi
Aug 1, 1994·Journal of the American College of Cardiology·D S CelermajerJ E Deanfield
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D B LubahnO Smithies
Aug 15, 1996·The New England Journal of Medicine·F GrodsteinC H Hennekens
Jul 1, 1996·The Journal of Clinical Investigation·T Caulin-GlaserJ R Bender
Jun 13, 1998·Biochimica Et Biophysica Acta·C S WingroveJ C Stevenson
Jul 31, 1998·Cardiovascular Research·E Van BelleJ M Isner
Jun 16, 1999·Endocrine Reviews·J F Couse, K S Korach
Nov 25, 2000·Journal of the American College of Cardiology·B Chandrasekar, J F Tanguay
Nov 22, 2001·Journal of Applied Physiology·D M Herrington, K P Klein
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·C PendariesJ F Arnal
Feb 28, 2002·Cardiovascular Research·Mark A Sader, David S Celermajer
Jun 1, 2002·Circulation Research·Gary PareMichael E Mendelsohn
Jul 19, 2002·JAMA : the Journal of the American Medical Association·Jacques E RossouwUNKNOWN Writing Group for the Women's Health Initiative Investigators
Oct 10, 2002·Endocrine Reviews·Ken L Chambliss, Philip W Shaul
Oct 16, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Pedro GeraldesJean-François Tanguay
Oct 17, 2002·Vascular Pharmacology·Gabor M RubanyiKatalin Kauser
Nov 2, 2002·Circulation Research·Christopher E IhionkhanPhilip W Shaul
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Lei LiJeffrey R Bender
Apr 15, 2004·JAMA : the Journal of the American Medical Association·Garnet L AndersonUNKNOWN Women's Health Initiative Steering Committee
Nov 20, 2004·Science·Karine M EganGarret A Fitzgerald
Feb 12, 2005·Molecular Endocrinology·Ellis R Levin
Feb 16, 2005·Annual Review of Physiology·Dean P Edwards
Mar 31, 2005·Molecular and Cellular Biology·Serena GhislettiElisabetta Vegeto
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Geneviève SoucySerge Rivest
May 11, 2005·Maturitas·Thomas B Clarkson, Susan E Appt
Jun 11, 2005·Science·Michael E Mendelsohn, Richard H Karas
Jul 16, 2005·Journal of Applied Physiology·Virginia M MillerNanette Santoro
Apr 8, 2006·Physiological Reviews·Alain Tedgui, Ziad Mallat
Aug 18, 2006·Molecular Aspects of Medicine·Paolo AscenziMaria Marino

❮ Previous
Next ❯

Citations

Jul 21, 2012·Cell and Tissue Research·Matteo SumanAntonella Peruffo
Dec 25, 2013·Endocrine·Vivekananda Gupta SunkariSergiu-Bogdan Catrina
Jun 7, 2013·Aging Clinical and Experimental Research·Hugo A P SantanaHerbert G Simões
Feb 1, 2012·Journal of Developmental Origins of Health and Disease·S C NewcomerR Cabot
Jul 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Audrey Billon-GalésJean-François Arnal
Feb 26, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Inmaculada C VillarAmrita Ahluwalia
Sep 29, 2011·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Pierre-Julien MoroMonique Bernard
Feb 23, 2012·Journal of Molecular Endocrinology·Jerzy-Roch Nofer
Jan 2, 2013·Frontiers in Bioscience (Scholar Edition)·Pandu R GangulaDiane Moseberry
Feb 15, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Cristina VassalleFaustino R Pérez-López
Mar 21, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Mehmet Gungor KayaFahrettin Kelestimur
Apr 6, 2016·Endocrine Research·Claudia VanettiMaria Grazia Cattaneo
Oct 21, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·O A MelkozerovaP B Tsyvian
Apr 30, 2013·Journal of Cardiovascular Pharmacology and Therapeutics·Marco Matteo CicconeEttore Cicinelli
May 9, 2018·Inflammation·Sueli Gomes FerreiraLuiz Felipe Pinho Moreira
May 18, 2018·Australian Dental Journal·E L MorelliW M Thomson
Aug 20, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Marion GayardMalvyne Rolli-Derkinderen
Apr 5, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Kahena TarhouniDaniel Henrion
Apr 24, 2014·Journal of the American Heart Association·Yipeng SuiChangcheng Zhou
Mar 11, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Arthur P ArnoldKathryn Sandberg
Apr 1, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Caroline ChenuFrançoise Lenfant
Jan 5, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·K TarhouniD Henrion
Sep 3, 2011·Circulation Research·Elizabeth Murphy
Dec 18, 2012·Periodontology 2000·Angelo Mariotti
Dec 18, 2012·Periodontology 2000·Angelo Mariotti, Michael Mawhinney
Mar 30, 2017·The Journal of Pharmacology and Experimental Therapeutics·Annalisa TrentiChiara Bolego
Apr 23, 2014·British Journal of Pharmacology·V BrancaleoneG Cirino
Mar 24, 2015·The Journal of Reproduction and Development·Lingfa KongGen Watanabe

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Homeostasis

Cardiovascular regulation and homeostasis is important in maintaining health and dysfunction may lead to cardiovascular diseases. Nitric oxide and vascular endothelium are one of many molecules involved in the homeostatic mechanism. Here is the latest research on cardiovascular homeostasis.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.