PMID: 9419778Jul 1, 1994Paper

Estrogen receptors are identified in the glioblastoma cell line U138MG

Journal of the Society for Gynecologic Investigation
K K LeslieF Naftolin

Abstract

The antiestrogen tamoxifen has been found to be effective in decreasing glioblastoma cell proliferation, but the mechanism underlying this effect and whether it is through the estrogen receptor (ER) is controversial. The objective of this study was to determine whether ERs are present in three human glioblastoma cell lines--HS683, U138MG, and JHN J889H--using the most sensitive techniques available. Ligand binding and flow cytometry were employed to identify estrogen and progesterone receptors. The reverse transcriptase-polymerase chain reaction was used to identify ER mRNA, and a novel reporter gene transfection assay demonstrated that the ER was capable of activating gene transcription. U138MG glioblastoma cells contain ERs that are capable of increasing gene transcription in response to estradiol. No ERs were found in HS683 or JHN J889H cells. Tamoxifen may be acting through the ER in some glioblastoma cells.

References

Apr 1, 1976·Journal of the National Cancer Institute·R B OwensE L Springer
Apr 1, 1992·American Journal of Obstetrics and Gynecology·K K LeslieK B Horwitz
May 1, 1990·Cancer·R Romić StojkovićS Gamulin
Jan 1, 1986·Journal of Steroid Biochemistry·C F HolinkaE Gurpide
Jan 1, 1968·Acta Pathologica Et Microbiologica Scandinavica·J Pontén, E H Macintyre
Dec 1, 1971·British Journal of Cancer·P FehertyA E Kellie
Jan 1, 1983·Journal of Neuro-oncology·M PoissonD Philibert
Jan 1, 1984·Clinical Neuropharmacology·M M BrentaniJ P Plese
Jan 1, 1984·Clinical Neuropharmacology·M FujimotoT Tamaya

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Citations

Dec 13, 2006·Journal of Toxicology and Environmental Health. Part a·Rebecca L Merritt, Christy M Foran
Jul 22, 2014·BMC Medical Genomics·Feng TianZhenjun Hu
Sep 16, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Geoffrey C KabatThomas E Rohan

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