Estrogen regulates the gene expression of vasoactive intestinal peptide in the anterior pituitary

Neuroendocrinology
K S LamS Reichlin

Abstract

Vasoactive intestinal peptide (VIP), a prolactin (PRL)-releasing factor, has been shown to be synthesized within the anterior pituitary. To test the hypothesis that estrogens increase PRL secretion, at least in part, by stimulating VIP secretion, the concentrations of VIP, peptide histidine isoleucine (PHI) and prepro VIP mRNA were measured in the anterior pituitaries of oophorectomized rats treated with 17 beta-estradiol benzoate 25 micrograms/kg/day s.c. for 5 days. For comparison, changes in the hypothalamus were also measured. Estrogen treatment resulted in a marked increase in pituitary VIP content without detectable changes in PHI content, suggesting that estrogen may regulate differentially the enzymes involved in the posttranslational processing of the VIP prohormone. A VIP mRNA-transcript of about 1.7 kilobases was detected in all tissues studied, being most abundant in the cortex, less abundant in the hypothalamus and barely detectable in the untreated pituitary. Estrogen treatment resulted in an increase in VIP gene expression in the pituitary but not in the hypothalamus or cerebral cortex. This marked increase in prepro VIP mRNA rendered possible the demonstration in the estrogen-treated pituitary of a second VIP tr...Continue Reading

Citations

Jan 1, 1993·Journal of Molecular Neuroscience : MN·I Gozes, D E Brenneman
Apr 1, 1995·Molecular Neurobiology·J M MullerA C Meunier
Nov 1, 1994·Brain Research. Molecular Brain Research·L GiardinoL Calzà
Oct 1, 1995·Brain Research. Molecular Brain Research·P J TolentinoE D Lamperti
Jan 1, 1994·Peptides·H Houben, C Denef
May 10, 2002·Journal of Neuroendocrinology·T Fiordelisio, A Hernández-Cruz
Oct 27, 1998·Stress : the International Journal on the Biology of Stress·W RosteneI Gozes
Feb 19, 2010·Animal Science Journal = Nihon Chikusan Gakkaihō·Gen HiyamaNorio Kansaku
Mar 1, 1996·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·D L MaasE C Drobny
Mar 5, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ana B F Emiliano, Julie L Fudge

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