PMID: 8613705Apr 1, 1996Paper

Estrogen regulation of JE/MCP-1 mRNA expression in fibroblasts

Journal of Leukocyte Biology
E J KovacsM R Frazier-Jessen

Abstract

We have recently demonstrated that 17 beta-estradiol (E2) inhibits peritoneal adhesion formation. Because macrophages play a central role in inflammation and wound healing, we chose to investigate whether the E2 could inhibit the expression of JE, the murine monocyte chemoattractant protein-1 (MCP-1). To accomplish this, murine fibroblasts were cultured with physiological concentrations of E2 (3-300 pg/ml) with or without inducers of JE/MCP-1 mRNA expression. Untreated cells failed to express the message, but, following stimulation, a marked increase in JE/MCP-1 mRNA expression was observed. At 10-30 pg/ml, E2 had no effect on JE/MCP-1 mRNA expression in stimulated fibroblasts. In contrast, lower and higher doses of E2 inhibited the expression of JE/MCP-1 mRNA in stimulated fibroblasts. Treatment with tamoxifen reversed the E2-inhibition of expression of the message. These data demonstrate that JE/MCP-1 mRNA expression is controlled, in part, by estrogen and suggest that macrophage recruitment may be affected by circulating levels of E2.

Citations

Jan 9, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·D W Losordo, J M Isner
Feb 3, 2007·Kidney & Blood Pressure Research·Barry B McGuireNeil G Docherty
Mar 4, 2011·Biogerontology·Elaine Emmerson, Matthew J Hardman
Feb 26, 2015·Advances in Wound Care·Timothy P PlackettElizabeth J Kovacs
Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·D L GordonM H Brooks
Oct 9, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·S PervinL Nathan
Jul 21, 2007·Endocrine Reviews·Rainer H Straub
Jan 17, 2004·American Journal of Reproductive Immunology : AJRI·Kelly JanisSusan M Aronica
Apr 3, 2001·The Journal of Comparative Neurology·M Blurton-Jones, M H Tuszynski
Mar 2, 2002·Fertility and Sterility·Emre SeliAydin Arici

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