PMID: 8955499Nov 1, 1996Paper

Estrogen regulation of lactoferrin expression in human endometrium

American Journal of Reproductive Immunology : AJRI
M E KelverM Nagamani

Abstract

Lactoferrin is an iron-binding glycoprotein that has been shown to be overexpressed in human endometrial carcinomas. The purpose of our present study is to investigate the possible role of estradiol in the expression of lactoferrin. We investigated 1) serum levels of lactoferrin in five women during normal ovulatory cycles, 2) serum levels of lactoferrin during ten human menopausal gonadotropin induced cycles when estradiol levels are high, and 3) lactoferrin expression in five proliferative and five secretory phase endometrium by immunohistochemical studies. The serum concentrations of lactoferrin were measured by a peroxidase-based enzyme-linked immunosorbent assay. In normal ovulatory cycles, the mean serum lactoferrin concentration during the proliferative phase (0.4013 +/- 0.0242 micrograms/mL) was significantly higher (P < 0.02) than in the secretory phase (0.3468 +/- 0.0209 micrograms/mL). In induced cycles, there was gradual increase in lactoferrin levels with increasing estradiol concentrations. Peak lactoferrin levels in induced cycles (0.7495 +/- 0.1148 micrograms/mL) were significantly higher (P < 0.003) than the midcycle levels (0.423 +/- 0.0424 micrograms/mL) in normal cycles. Immunohistochemical analysis of the e...Continue Reading

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Citations

Feb 18, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hiroyoshi InoueKozue Kaibara
May 29, 2000·Reproductive Toxicology·W N JeffersonR R Newbold
May 7, 2003·The Journal of Steroid Biochemistry and Molecular Biology·C PunyadeeraP Groothuis
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Jun 2, 2020·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Estefanía MassaSergio Ghersevich

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