Abstract
Phosphoserine phosphatase (PSPH) is a well-known mediator of l-serine biosynthesis in a variety of tissues and its dysregulation causes various diseases, specifically most cancers. However, little is known about the expression and hormonal regulation of PSPH gene in the female reproductive tract. Therefore, in the current study, we focused on relationships between PSPH expression and estrogen during growth, development, differentiation, remodeling and recrudescence of the chicken oviduct and in the progression of epithelial-derived ovarian carcinogenesis in laying hens. The results revealed that PSPH mRNA and protein levels increased in the glandular (GE) and luminal epithelial (LE) cells in the developing oviduct of chicks treated with exogenous estrogen. Additionally, PSPH mRNA and protein expression was up-regulated in GE and LE of the oviduct in response to endogenous estrogen during the recrudescence phase after induced molting. Furthermore, PSPH mRNA and protein were predominantly detected in GE of cancerous, but not normal ovaries. In conclusion, PSPH is a novel estrogen-responsive gene involved in development of the oviduct of chicks and recrudescence of the oviduct of laying hens after molting. PSPH is also a potential...Continue Reading
References
Oct 1, 1975·Endocrinology·T A SanbornH J Sallach
Sep 1, 1978·Cancer·A HerzfeldO Greengard
Aug 23, 1988·Biochemistry·M M Sanders, G S McKnight
Nov 20, 1987·Biochimica Et Biophysica Acta·F A Simmen
Sep 1, 1971·The Journal of Cell Biology·R D Palmiter, J T Wrenn
Dec 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·B W O'Malley, P O Kohler
Jan 1, 1969·The Journal of Cell Biology·P O KohlerB W O'Malley
Oct 1, 1996·Journal of Neurochemistry·P L WoodD B Goodnough
Mar 10, 2001·Biochemical and Biophysical Research Communications·E StrunckG Vollmer
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jun 24, 2003·Poultry Science·W D Berry
Feb 1, 2008·Cell and Tissue Research·K K Chousalkar, J R Roberts
Oct 22, 2008·Birth Defects Research. Part A, Clinical and Molecular Teratology·Ivon J M van der LindenHenk J Blom
Jun 11, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Animesh BaruaJudith L Luborsky
Dec 8, 2009·Molecular Genetics and Metabolism·L TabatabaieT J de Koning
Mar 31, 2010·Breast Cancer Research and Treatment·Sirkku PollariOlli Kallioniemi
May 6, 2011·Biology of Reproduction·Gwonhwa SongJae Yong Han
Jul 6, 2011·Journal of Dermatological Science·Michael A BachelorDavid M Owens
Jan 1, 2010·Hormones & Cancer·Lindsey S TreviñoPatricia Ann Johnson
Aug 19, 2011·Biology of Reproduction·Whasun LimGwonhwa Song
Feb 1, 2012·Experimental Biology and Medicine·Whasun LimGwonhwa Song
Feb 22, 2012·Clinical Obstetrics and Gynecology·Christopher P CrumWa Xian
Apr 13, 2012·PloS One·Jin-Young LeeGwonhwa Song
May 17, 2013·Nature Reviews. Cancer·Patricia A Johnson, James R Giles
Sep 24, 2013·Molecular and Cellular Endocrinology·Seung-Min BaeGwonhwa Song
Oct 8, 2013·PloS One·Wooyoung JeongGwonhwa Song
Jan 15, 2014·Nature Communications·Adil MardinogluJens Nielsen