Estrogen-related genes and postmenopausal osteoporosis risk

Climacteric : the Journal of the International Menopause Society
N MendozaT Martínez Astorquiza

Abstract

To date, more than 150 candidate genes related to osteoporosis have been described, but osteoporosis has increasingly been considered a polygenic disease modulated by environmental factors. It is thought that osteoporosis predisposition, pathology, and treatment response depend on the interaction between different genes or between genes and environmental factors. The aim of this study was to evaluate the relationship between the presence of single nucleotide polymorphisms (SNPs) in the estrogen metabolic pathway and the development of osteoporosis and to determine whether this relationship is monogenic or whether interactions between genes exist. A multicentric study with 1980 postmenopausal Spanish women in five Spanish communities was conducted. The women completed a specific questionnaire that inquired about risk factors for osteoporosis. Data on participants' bone mineral density were obtained with dual-energy X-ray densitometers, and genetic data were obtained from frozen peripheral blood. The digenic protection combinations indicated involvement of the wild-type genotype (WT) of the 3'UTR marker for the CYP19A1 gene, the IVS4 marker of the same gene, and the BMP15 and FSHR genes. Among patients who carried two or more of ...Continue Reading

References

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Citations

Jun 9, 2015·Bone·Gonzalo Sánchez-DuffhuesPeter Ten Dijke
Mar 21, 2018·The Journal of Endocrinology·Mone ZaidiTony Yuen
Sep 10, 2014·Endocrine Reviews·Dirk VanderschuerenClaes Ohlsson
Aug 26, 2014·Molecular Endocrinology·Mohan LiuRichard M Weinshilboum
Aug 8, 2018·Endocrinology·Mone ZaidiTony Yuen
Mar 19, 2020·Menopause : the Journal of the North American Menopause Society·Tzu-Liang HsuYung-Po Liaw
Apr 4, 2019·Frontiers in Endocrinology·Daria LiznevaMone Zaidi

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