Estrogen-related MxA transcriptional variation in hepatitis C virus-infected patients

Translational Research : the Journal of Laboratory and Clinical Medicine
Radwa Y MekkyAhmed Ihab Abdelaziz

Abstract

Sex has been reported to influence the rates of viral clearance in hepatitis C virus (HCV)-infected patients. However, little is known regarding the influence of sex on the host genetic response to HCV, which is mediated by the expression of interferon (IFN)-stimulated genes (ISGs) after the activation of janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway by IFN. Thus, we investigated gender differences in MxA genetic profile, which is a downstream reliable marker for JAK/STAT pathway activation. In all, 40 untreated HCV-infected patients were subclassified into premenopausal, postmenopausal, and male patients. The peripheral blood mononuclear cells (PBMCs) from premenopausal women showed the highest MxA gene expression compared to both postmenopausal females and males before and after IFN stimulation. The prestimulation of PBMCs with 17beta-estradiol prior to IFN treatment resulted in a decrease of MxA expression in all groups of patients. That was confirmed by the reversal of this effect using estrogen antagonist ICI182/780. This study demonstrates for the first time the presence of gender variations in the genetic response to chronic HCV infection and to interferon treatment. It also clarifies...Continue Reading

References

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Citations

Oct 15, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·John Denis RyanJohn Crowe
Mar 13, 2014·Journal of Medical Virology·Injie O FawzyAhmed I Abdelaziz
Nov 26, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Andrea MagriMario Pirisi
Dec 12, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Elizabeth M KieferKathryn Anastos
Dec 26, 2012·Expert Review of Gastroenterology & Hepatology·Radwa Y Mekky, Ahmed I Abdelaziz
Jan 7, 2015·World Journal of Gastroenterology : WJG·Xin ChengDian-Xing Sun

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