Estrogen-related receptor alpha: an orphan finds a family.

Breast Cancer Research : BCR
Aleksandra M Ochnik, Douglas Yee

Abstract

Identification of molecules and their effectors has led to new therapies designed to specifically inhibit pathways in molecularly defined breast cancer subtypes. An orphan nuclear receptor, estrogen-related receptor alpha, has been shown to be a downstream target of two tyrosine kinase growth factor receptors: human epidermal growth factor receptor 2 and the type I insulin-like growth factor receptor. Identifying the mechanistic actions of orphan nuclear receptors could lead to new biomarkers and molecular targets in malignancy.

References

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Oct 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yasutomi KameiAkira Kakizuka
Dec 16, 2010·The Oncologist·Charles M Perou
Dec 15, 2010·Molecular Oncology·Aleix Prat, Charles M Perou
Oct 8, 2011·Breast Cancer Research : BCR·Achim RodyManfred Kaufmann

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Citations

Jun 4, 2015·Journal of Receptor and Signal Transduction Research·Harmit S Ranhotra
Oct 9, 2015·Journal of Receptor and Signal Transduction Research·Harmit S Ranhotra

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