PMID: 16515477Mar 7, 2006Paper

Estrogen-related receptors as emerging targets in cancer and metabolic disorders

Current Topics in Medicinal Chemistry
Eric A Ariazi, V Craig Jordan

Abstract

While estrogen receptor (ER)-targeted therapeutics have clearly been a success in the treatment of breast cancer, the orphan estrogen-related receptors (ERRs) represent novel targets for future development. The ERRs, comprising ERRalpha, ERRbeta and ERRgamma, bind and regulate transcription via estrogen response elements (EREs) and extended ERE half-sites termed ERR response elements (ERREs), but do not bind endogenous estrogens. The emerging role of ERRalpha and ERRgamma in modulating estrogen responsiveness, substituting for ER activities, and serving as prognosticators in breast and other cancers is providing an impetus for the identification of compounds which target these proteins. Moreover, ERRalpha plays a role in energy homeostasis and will likely be targeted for the treatment of metabolic disorders. Multiple classes of synthetic ligands have already been identified. The phytoestrogens genistein, daidzein, biochanin A and 6,3'4'-tryhydroxyflavone have been reported as ERRalpha agonists. The phenolic acyl hydrazones GSK4716 and GSK9089 act as selective agonists of ERRbeta and ERRgamma. The organochlorine pesticides toxaphene and chlordane, and the synthetic compound XCT790 antagonize ERRalpha. The synthetic estrogen diet...Continue Reading

Citations

May 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ada AoJianrong Lu
Jun 24, 2009·The Journal of Biological Chemistry·Stéphanie BiancoJean-Marc Vanacker
Jul 27, 2010·The Journal of Biological Chemistry·Muralimohan YepuruRamesh Narayanan
Feb 13, 2013·Journal of Medicinal Food·Malika Bouchenak, Myriem Lamri-Senhadji
Aug 14, 2008·Nucleic Acids Research·Catherine TeyssierJean-Marc Vanacker
Oct 16, 2012·Molecular Pharmacology·Susan M Krzysik-WalkerMichel Bernier
Apr 24, 2007·Biochemistry. Biokhimii︠a︡·Yu S LobanovaM A Krasil'nikov
Mar 26, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Wun-Chang KoChung-Hung Shih
Jan 10, 2013·BMC Complementary and Alternative Medicine·Linette Castillo-PichardoSuranganie Dharmawardhane
Apr 18, 2008·Molecular Endocrinology·Suzanne D Conzen
Dec 8, 2009·Molecular Endocrinology·William A AlaynickAndrew N Billin
Jul 12, 2007·Journal of Cell Science·Hiroaki YasumotoRobert Y L Tsai
Feb 16, 2012·Journal of Molecular Endocrinology·Kathryn L AuldRobert V Martinez
Jan 12, 2010·Cellular and Molecular Life Sciences : CMLS·Albane le MairePatrick Balaguer
Jan 15, 2014·Molecular Therapy : the Journal of the American Society of Gene Therapy·Sophia Sn LamAlice St Wong
Mar 10, 2009·Environmental Health Perspectives·Elizabeth W LapenseeNira Ben-Jonathan
Jul 7, 2011·Expert Review of Endocrinology & Metabolism·Gila IdelmanNira Ben-Jonathan
Jan 16, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jina KimSung Jin Cho
Jan 25, 2012·Journal of Receptor and Signal Transduction Research·Harmit S Ranhotra
May 1, 2007·Expert Opinion on Drug Discovery·Chang BaiAzriel Schmidt
Jan 9, 2016·The Science of the Total Environment·Myriam BorgattaNathalie Chèvre
Jan 24, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Zhixiang XuXuejun Pan
Feb 14, 2013·Molecular and Cellular Endocrinology·Martial KammererBrigitte Fournier
Mar 19, 2011·The Journal of Steroid Biochemistry and Molecular Biology·Stéphanie BiancoJean-Marc Vanacker
Jun 16, 2015·Environment International·Ryoiti Kiyama, Yuko Wada-Kiyama
Sep 10, 2008·Trends in Endocrinology and Metabolism : TEM·Josep A Villena, Anastasia Kralli
Sep 13, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Haixing SongKun Zhang
Jun 6, 2008·Molecular and Cellular Endocrinology·Dominique GalloGuy Leclercq
Oct 27, 2015·Gynecologic Oncology·M LagerstedtS-L Laasanen
Feb 6, 2007·Toxicology and Applied Pharmacology·Krystal FontenotWesley Gray
Oct 9, 2015·Journal of Receptor and Signal Transduction Research·Harmit S Ranhotra
Aug 18, 2006·Molecular Aspects of Medicine·Paolo AscenziMaria Marino
Apr 5, 2016·International Journal of Molecular Sciences·Dan WangJian-Jun Mu

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