Estrogen replacement attenuates resistance artery adrenergic sensitivity via endothelial vasodilators

The American Journal of Physiology
M C MeyerG Osol

Abstract

The objective of this study was to determine whether chronic estrogen replacement alters adrenergic constriction and endothelium-dependent dilation in resistance arteries from the rat. Resistance-sized (< 200 microns) mesenteric arteries from castrated female Sprague-Dawley rats with (E2; 21 day, 0.5-mg pellet) and without (OvX) estrogen replacement were removed for in vitro study on a pressurized arteriograph system. Sensitivity to alpha-adrenergic constriction and the role of the endothelium in its modulation and of agonist-provoked endothelium-dependent relaxation were determined. Estrogen-treated rats had decreased heart rate as well as systolic and diastolic blood pressure. Arteries from estrogen-replaced rats were fivefold less sensitive to alpha 1-adrenergic stimulation with phenylephrine (50% effective concentration: E2, 3.2 +/- 1.1 microM; OvX, 0.6 +/- 0.2 microM; P < 0.05). This difference was abolished by endothelial denudation, blockade of cyclooxygenase (1 microM ibuprofen), or nitric oxide synthase blockade (0.24 mM N omega-nitro-L-arginine). There was no difference in muscarinic agonist-provoked relaxation or vascular smooth muscle sensitivity to prostacyclin or sodium nitroprusside. These results indicate that e...Continue Reading

Citations

Mar 15, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Jose A OspinaDiana N Krause
Jan 6, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Javier PalaciosLuis Michea
Nov 17, 2010·The Journal of Physiology·Dirk J Duncker, Daphne Merkus
Feb 25, 2009·The Journal of Physiology·Qi FuBenjamin D Levine
Dec 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·Dan P StephensJohn M Johnson
Jun 13, 2012·The Journal of Physiology·Sara S JarvisQi Fu
Jan 7, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Julia M Orshal, Raouf A Khalil

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