Estrogen replacement in surgical stage I and II endometrial cancer survivors

American Journal of Obstetrics and Gynecology
J A ChapmanM L Berman

Abstract

Our purpose was to evaluate our experience with estrogen replacement in women with a history of early-stage endometrial cancer and to determine whether it increased the risk for recurrence or death. A retrospective review was performed of 123 women with surgical stage I and II endometrial adenocarcinoma treated between 1984 and 1994; 62 had received estrogen replacement therapy after cancer therapy. Sixty-one women received no estrogen. Variables analyzed included age parity, surgical stage, grade, depth of myometrial invasion, presence of intercurrent illnesses, duration of follow-up, and duration of estrogen replacement, if applicable. Outcome variables assessed included recurrence rate, time to recurrence, and disease-free interval. The estrogen replacement therapy group had earlier stage disease (p = 0.04) and less severe depth of invasion (p = 0.003); however, the total number of deaths in each group was not significantly different. The disease-free survival in the estrogen replacement therapy group did not differ significantly compared with those not receiving estrogen replacement therapy. The data are suggestive of improved disease-free survival in the estrogen replacement therapy group, which may be related to differenc...Continue Reading

Citations

Jul 23, 2004·World Journal of Surgical Oncology·Karsten MünstedtHans-Rudolf Tinneberg
Aug 10, 2007·Gynecologic and Obstetric Investigation·Siriwan TangjitgamolJohn J Kavanagh
May 24, 2003·Best Practice & Research. Clinical Endocrinology & Metabolism·M GambaccianiA R Genazzani
Jun 18, 2002·Maturitas·Toon Van Gorp, Patrick Neven
May 26, 1999·Maturitas·C LiC Iosif
Apr 17, 2002·Maturitas·Adolf E Schindler
Oct 4, 2002·Maturitas·Hermann P G Schneider
Jul 31, 2004·Maturitas·Nicoletta BigliaPiero Sismondi
May 11, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·V LoizziL Selvaggi
May 10, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A AyhanAtike Sever
Feb 2, 2002·Current Oncology Reports·Philip J DiSaia, Wendy R Brewster
Jun 13, 2012·Archives of Gynecology and Obstetrics·Ozgur AkbayırAhmet Cetin
Nov 23, 2011·Gynécologie, obstétrique & fertilité·P This
Jun 9, 2014·Journal of the Chinese Medical Association : JCMA·Hei-Yu LauYi-Jen Chen
Jul 25, 2015·Journal of Women's Health·Stephanie S FaubionPetra M Casey
Mar 7, 2015·International Journal of Clinical Oncology·Yoshihito YokoyamaUNKNOWN Disease Committee of Uterine Cancer, Japanese Gynecologic Oncology Group
Apr 24, 2012·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·I BiliatisA Antsaklis
Sep 6, 2015·Maturitas·Nicoletta BigliaMartina Gallo
Nov 12, 2010·Climacteric : the Journal of the International Menopause Society·T SekijimaM Ohmichi
Mar 24, 2011·Climacteric : the Journal of the International Menopause Society·L S G Ulrich
Aug 21, 2013·Climacteric : the Journal of the International Menopause Society·F Guidozzi
Jan 20, 2010·Climacteric : the Journal of the International Menopause Society·K HanckeD Denschlag
May 13, 2015·Cancer Causes & Control : CCC·Ashley S FelixLouise A Brinton
Jun 25, 2002·Gynecologic Oncology·William T Creasman
Apr 2, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Seung-Hyuk ShimSoo-Nyung Kim
Sep 14, 2016·Maturitas·Carol L KuhleStephanie S Faubion
Feb 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard R BarakatUNKNOWN Gynecologic Oncology Group Study
Jan 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jason D WrightThomas J Herzog
Jun 20, 2017·Gynecologic Oncology·Marcela G Del Carmen, Laurel W Rice
Nov 1, 2001·Clinical Obstetrics and Gynecology·J B Basil, D G Mutch
Feb 20, 2013·Nature Reviews. Endocrinology·Serge RozenbergCaroline Antoine
Jan 9, 2019·Pathology Oncology Research : POR·Tamás DeliAttila Jakab
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·K. YamazawaS. Sekiya
Jul 10, 2009·Current Opinion in Oncology·Rachel Michaelson-Cohen, Uziel Beller
Oct 6, 2010·Journal of Gynecologic Oncology·Nan-Hee JeongSeon-Kyung Lee
Aug 12, 2005·Current Opinion in Oncology·William T Creasman
Oct 28, 2006·Gynäkologisch-geburtshilfliche Rundschau·Nicoletta BigliaPiero Sismondi
Oct 2, 2004·Obstetrics and Gynecology·UNKNOWN American College of Obstetricians and Gynecologists Women's Health Care Physicians
Mar 24, 2010·Obstetrics and Gynecology·Jan L Shifren, Isaac Schiff
Apr 26, 2019·The Journal of International Medical Research·Tianjiao LyuWeiwei Feng
Dec 3, 2015·Current Opinion in Obstetrics & Gynecology·Rachel Louise O'DonnellRichard J Edmondson
Feb 13, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Margaret ReesCorrado Terranova
Mar 4, 1998·Current Opinion in Obstetrics & Gynecology·S D Yamada, K F McGonigle
Nov 26, 1999·Clinical Obstetrics and Gynecology·V Mahavni, R E Buller

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.