Estrogen replacement treatment in diabetic ovariectomized female rats potentiates postischemic leukocyte adhesion in cerebral venules

Stroke; a Journal of Cerebral Circulation
Hao-Liang XuD A Pelligrino

Abstract

Chronic 17beta-estradiol (E2) replacement therapy in ovariectomized (OVX) female rats reduces leukocyte adhesion and brain damage after transient forebrain ischemia. Recently, we found that E2 treatment in diabetic OVX females was associated with enhanced postischemic neuropathology. We tested the hypothesis that in chronically hyperglycemic diabetic OVX females, chronic E2 replacement potentiates post-transient forebrain ischemia leukocyte adhesion. Pial venules were observed through closed cranial windows. Adherence of rhodamine 6G-tagged leukocytes was monitored before and 10 hours after transient forebrain ischemia (20 minutes right common carotid artery occlusion plus hemorrhagic hypotension) in intact, untreated OVX and E2-treated OVX females rendered diabetic via streptozotocin. Leukocyte adhesion was quantitated as the percentage venular area occupied by adherent leukocytes. At 2 hours after transient forebrain ischemia, a similar low level of leukocyte adhesion was seen in the 3 groups (<3% of the venular area). Starting at approximately 4 hours after ischemia, leukocyte adhesion in the E2-treated OVX females rose to significantly higher levels compared with the other groups. Relative to the 2-hour value, the level of ...Continue Reading

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Citations

Feb 10, 2010·Menopause : the Journal of the North American Menopause Society·Olga N LekontsevaSandra T Davidge
Oct 13, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Hao-Liang XuDale A Pelligrino
Jul 19, 2008·Anesthesia and Analgesia·Kamila VagnerovaPatricia D Hurn
Jul 19, 2008·Anesthesia and Analgesia·Michael P HutchensPer O Jarnberg
Jun 16, 2011·International Journal of Molecular Sciences·Jakob O StromElvar Theodorsson
Jan 30, 2014·Molecular and Cellular Endocrinology·Limor Raz
Jul 10, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lan WangStephanie J Murphy
Dec 17, 2009·Clinical Science·Hilary V O CarswellTracy D Farr
Jan 28, 2015·Journal of Neuroinflammation·Hao-Liang XuFernando D Testai
Sep 1, 2007·NeuroImage·Francesco VetriAntonio Colantuoni
Sep 13, 2016·Frontiers in Neurology·Wentao LiFernando D Testai
Jun 24, 2006·Journal of Applied Physiology·Diana N KrauseDale A Pelligrino

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