Estrogen repression of microRNA as a potential cause of cancer

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Amit CohenYoav Smith

Abstract

MicroRNAs (miRNAs) are endogenous small molecules that regulate gene expression and have been implicated in the pathogenesis of many human diseases, including cancer. This review describes the results that show a global repression in miRNA expression in various tumors and cancer cell lines. Intriguingly, recent discoveries have shown a widespread downregulation of miRNA after exposure to the steroid hormone estrogen. The integration of the results suggests that estrogen-dependent repression of miRNA is a potential cause of cancer.

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Citations

Jul 26, 2016·Frontiers in Neuroscience·Adel DerghalLourdes Mounien
Oct 23, 2016·Fish & Shellfish Immunology·Mario Alberto Burgos-AcevesCaterina Faggio
Mar 23, 2017·World Journal of Gastroenterology : WJG·Jie WangJian-Xin Jiang
Dec 12, 2017·Cancer Biomarkers : Section a of Disease Markers·Ze HongHaixiao Qi
Jul 3, 2020·International Journal of Molecular Sciences·Paulína PidíkovaIveta Herichova

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