Estrogen Restores Multisynaptic Boutons in the Dorsolateral Prefrontal Cortex while Promoting Working Memory in Aged Rhesus Monkeys

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Yuko HaraJohn H Morrison

Abstract

Humans and nonhuman primates are vulnerable to age- and menopause- related decline in working memory, a cognitive function reliant on area 46 of the dorsolateral prefrontal cortex (dlPFC). We showed previously that presynaptic mitochondrial number and morphology in monkey dlPFC neurons correlate with working memory performance. The current study tested the hypothesis that the types of synaptic connections these boutons form are altered with aging and menopause in rhesus monkeys and that these metrics may be coupled with mitochondrial measures and working memory. Using serial section electron microscopy, we examined the frequencies and characteristics of nonsynaptic, single-synaptic, and multisynaptic boutons (MSBs) in the dlPFC. In contrast to our previous observations in the monkey hippocampal dentate gyrus, where MSBs comprised ∼40% of boutons, the vast majority of dlPFC boutons were single-synaptic, whereas MSBs constituted a mere 10%. The frequency of MSBs was not altered by normal aging, but decreased by over 50% with surgical menopause induced by ovariectomy in aged monkeys. Cyclic estradiol treatment in aged ovariectomized animals restored MSB frequencies to levels comparable to young and aged premenopausal monkeys. Nota...Continue Reading

Citations

Oct 4, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Heather M SnyderMaria C Carrillo
Apr 6, 2019·British Journal of Pharmacology·Pedram Honarpisheh, Louise D McCullough
Jul 25, 2019·Frontiers in Human Neuroscience·Caitlin M TaylorEmily G Jacobs
Sep 24, 2019·Endocrine Reviews·Elisabetta VegetoAngelo Poletti
Dec 15, 2019·Scientific Reports·Deepali C SenguptaElizabeth M Quinlan
Aug 1, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jason K RussellPaul A Newhouse
Oct 12, 2018·Current Psychiatry Reports·Elizabeth Hampson
Jul 8, 2020·NeuroImage·Caitlin M TaylorEmily G Jacobs
Feb 18, 2021·Proceedings of the National Academy of Sciences of the United States of America·Eric W BussDaniel A Nicholson
Jul 7, 2021·Physiology & Behavior·Gladys A ShawGretchen N Neigh
Jul 19, 2021·Cerebral Cortex·Sentao WangYang Zhan
Jul 14, 2021·American Journal of Primatology·Carmen Freire-CoboPatrick R Hof
Aug 28, 2021·International Journal of Molecular Sciences·Yu-Jung ChengHsien-Yuan Lane

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.