Estrogen, Stress, and Depression: Cognitive and Biological Interactions

Annual Review of Clinical Psychology
Kimberly M Albert, Paul A Newhouse

Abstract

This article reviews the interactions of estrogen changes and psychosocial stress in contributing to vulnerability to major depressive disorder (MDD) in women. Estrogen modulates brain networks and processes related to changes in stress response, cognition, and emotional dysregulation that are core characteristics of MDD. Synergistic effects of estrogen on cognitive and emotional function, particularly during psychosocial stress, may underlie the association of ovarian hormone fluctuation and depression in women. We propose a model of estrogen effects on multiple brain systems that interface with stress-related emotional and cognitive processes implicated in MDD and discuss possible mechanisms through which reproductive events and changes in estrogen may contribute to MDD risk in women with other concurrent risk factors.

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Citations

Jul 3, 2020·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·Beate Herpertz-DahlmannJoseph Neulen
Mar 28, 2021·Annals of General Psychiatry·Jamaan Al-ZahraniAshraf El-Metwally
May 7, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Marie CoenjaertsDirk Scheele
Jul 6, 2021·International Journal of Mental Health and Addiction·Yeliz SürmeBade Ertürk Arik
Mar 11, 2020·Neuroendocrinology·Elisa RehbeinBirgit Derntl

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Methods Mentioned

BETA
MDD

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