Estrogen suppresses activation but enhances formation phase of osteogenic response to mechanical stimulation in rat bone

The Journal of Clinical Investigation
C J JaggerT J Chambers

Abstract

We used a model whereby mechanical stimulation induces bone formation in rat caudal vertebrae, to test the effect of estrogen on this osteogenic response. Unexpectedly, estrogen administered daily throughout the experiments (8-11 d) suppressed, and ovariectomy enhanced, mechanically induced osteogenesis. Osteogenesis was unaffected by the resorption-inhibitor pamidronate, suggesting that the suppression of bone formation caused by estrogen was not due to suppression of resorption. We found that estrogen did not significantly reduce the proportion of osteocytes that were induced by mechanical stimulation to express c-fos and IGF-I mRNA; and estrogen suppressed mechanically induced osteogenesis whether administration was started 24 h before or 24 h after loading. This suggests that estrogen acts primarily not on the strain-sensing mechanism itself, but on the osteogenic response to signals generated by strain-sensitive cells. We also found that when estrogen administration was started 3 d after mechanical stimulation, by which time osteogenesis is established, estrogen augmented the osteogenic response. This data is consistent with in vitro evidence for estrogen responsiveness in two phenotypically distinct bone cell types: strom...Continue Reading

References

Dec 1, 1991·Bone and Mineral·D N Kalu
Jan 1, 1991·Bone·C H Turner
May 1, 1991·Journal of Biomechanical Engineering·S C CowinM L Moss
Jun 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G A Rodan
Jun 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M NotelovitzL McKenzie
Apr 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T J WronskiK S Scott
Feb 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P B GleesonH J Evans
Sep 1, 1988·Calcified Tissue International·T J WronskiL M Dann
Dec 1, 1988·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M J PeadL E Lanyon
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M ErnstE R Froesch
Dec 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A M ParfittR R Recker
Aug 1, 1980·European Journal of Clinical Investigation·C ChristiansenI Transbøl
Jan 1, 1984·Calcified Tissue International·L E Lanyon
Sep 1, 1984·Calcified Tissue International·Z F Jaworski
Mar 21, 1984·Journal of Theoretical Biology·C T Rubin, L E Lanyon
Feb 2, 1995·The New England Journal of Medicine·S C Manolagas, R L Jilka
Jul 1, 1994·The Journal of Endocrinology·J M LeanT J Chambers
Jul 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T AbeT J Chambers
Apr 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M Z ChengL E Lanyon

❮ Previous
Next ❯

Citations

Nov 20, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A D BakkerE H Burger
Sep 3, 2010·Current Osteoporosis Reports·Manasi AgrawalJameel Iqbal
Mar 23, 2005·Bone·L K Saxon, C H Turner
Jul 18, 2012·The Journal of Clinical Endocrinology and Metabolism·K DeereJ H Tobias
Feb 5, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A SamuelsJ H Tobias
Jul 14, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M R MoalliS A Goldstein
Jan 10, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M IkegameH Kawashima
Jul 14, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H ZhouR Lindsay
Sep 18, 2012·PloS One·Susannah J SamplePeter Muir
Aug 4, 2004·Journal of Oral Science·Guizhen JiangAkira Fujii
May 8, 2010·European Journal of Endocrinology·Jameel IqbalMone Zaidi
Jun 30, 2011·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Tsang-Hai HuangRong-Sen Yang
Nov 19, 2015·Der Unfallchirurg·M Haffner-LuntzerA Ignatius
Jul 16, 2008·Bone·Ilari PajamäkiTeppo L N Järvinen
Jun 12, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Helen L JessopLance E Lanyon
Dec 16, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Chi Hyun KimX Edward Guo
Sep 30, 2009·The Mount Sinai Journal of Medicine, New York·Mone ZaidiLi Sun
Oct 14, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Chiuan-Ren YehCheng-Kung Cheng
Aug 19, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Shu-Lu ChungWing-Hoi Cheung
Jan 15, 2015·Journal of Biomechanics·Jenneke Klein-NulendRommel G Bacabac
Jul 3, 2013·Clinical & Developmental Immunology·Graziana ColaianniSilvia Colucci
Sep 10, 2014·Endocrine Reviews·Dirk VanderschuerenClaes Ohlsson
May 5, 2010·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Mone ZaidiLi Sun
Sep 14, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sara H WindahlClaes Ohlsson
Dec 3, 2016·Innovative Surgical Sciences·Melanie Haffner-LuntzerAnita Ignatius
Feb 15, 2001·American Journal of Physiology. Endocrinology and Metabolism·M JoldersmaE H Burger
Nov 27, 2021·Current Osteoporosis Reports·Laoise M McNamara

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Thyroid : Official Journal of the American Thyroid Association
Peter MikoschPeter Pietschmann
The Journal of Clinical Endocrinology and Metabolism
MaryFran R SowersB Ettinger
Thyroid : Official Journal of the American Thyroid Association
D T Baran
© 2021 Meta ULC. All rights reserved