PMID: 8609426Apr 15, 1996Paper

Estrogen suppression of connective tissue deposition in a murine model of peritoneal adhesion formation

The Journal of Immunology : Official Journal of the American Association of Immunologists
M R Frazier-JessenE J Kovacs

Abstract

Estrogen's involvement in inflammation and wound healing is poorly understood. To examine the role of estrogen in peritoneal adhesion formation, we gave ovariectomized female C57BL/6 mice time-release pellets containing placebo, 0.05 mg 17 beta-estradiol (low E2), or 5 mg 17 beta-estradiol (high E2) before i.p. injection of talc in saline or saline alone. Analyses of abdominal wall connective tissue thickness and peritoneal cell populations were performed. Talc-treated mice receiving low and high E2 replacement had a decreased amount of abdominal connective tissue deposition (29% and 65% decrease, respectively) as compared with talc-treated mice receiving placebo pellets. At high E2 replacement, the difference in connective tissue deposition was significant statistically (p less than 0.01). Immunohistochemical analysis revealed that the number of macrophages in adhesion tissue was proportionate to the amount of connective tissue present, regardless of the circulating levels of E2. Northern blot analysis of abdominal wall tissue showed that five of six talc-treated animals given placebo expressed mRNA for the murine monocyte chemoattractant protein-1 (MCP-1), JE. Conversely, only one of five talc-treated animals that received E2...Continue Reading

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