PMID: 1603493Jul 1, 1992Paper

Estrogen use and depressive symptoms in postmenopausal women

Obstetrics and Gynecology
L A Palinkas, E Barrett-Connor

Abstract

The potential antidepressant effects of estrogen replacement therapy were examined cross-sectionally in a population of 1190 women 50 years and older living in Rancho Bernardo, California. Of the total, 294 (24.7%) were currently using estrogen. Among women aged 50-59 years, those currently using noncontraceptive estrogen had a significantly higher rate of Beck Depression Inventory scores of 13 or higher than all untreated women of the same age and higher mean depressive symptom scores than women who had never used estrogen. However, after age 60, mean depressive symptom scores and rates of categorical depression increased significantly in the untreated women but not in the treated women. A similar pattern was found when depressive symptom measures of treated and untreated women were stratified by the number of years since last menstrual period. Greater depressive symptoms in currently treated versus untreated women aged 50-59 years may reflect treatment selection bias, as a higher proportion of symptomatic depressed climacteric women seek treatment. The decreased risk of depressive symptoms after age 60 may reflect a long-term benefit of estrogen replacement or the selective discontinuation of estrogen by depressed women. In t...Continue Reading

Citations

Feb 27, 1993·Lancet·L A PalinkasD L Wingard
May 1, 1996·Social Science & Medicine·D DefeyG Fernández
May 1, 1996·Psychoneuroendocrinology·V W HendersonJ G Buckwalter
May 1, 1994·Experimental Gerontology·R W Rebar
Feb 13, 2004·Biological Psychiatry·Mary F MorrisonMichelle Battistini
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