Estrogenic Activity of Mineral Oil Aromatic Hydrocarbons Used in Printing Inks

PloS One
Patrick TarnowAndreas Luch

Abstract

The majority of printing inks are based on mineral oils (MOs) which contain complex mixtures of saturated and aromatic hydrocarbons. Consumer exposure to these oils occurs either through direct skin contacts or, more frequently, as a result of MO migration into the contents of food packaging that was made from recycled newspaper. Despite this ubiquitous and frequent exposure little is known about the potential toxicological effects, particularly with regard to the aromatic MO fractions. From a toxicological point of view the huge amount of alkylated and unsubstituted compounds therein is reason for concern as they can harbor genotoxicants as well as potential endocrine disruptors. The aim of this study was to assess both the genotoxic and estrogenic potential of MOs used in printing inks. Mineral oils with various aromatic hydrocarbon contents were tested using a battery of in vitro assays selected to address various endpoints such as estrogen-dependent cell proliferation, activation of estrogen receptor α or transcriptional induction of estrogenic target genes. In addition, the comet assay has been applied to test for genotoxicity. Out of 15 MOs tested, 10 were found to potentially act as xenoestrogens. For most of the oils th...Continue Reading

References

Oct 1, 1995·Environmental Health Perspectives·A M SotoF O Serrano
Jun 16, 1999·Endocrine Reviews·J F Couse, K S Korach
Jun 1, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·G D CharlesE W Carney
Nov 21, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jan VondrácekMiroslav Machala
Jan 30, 2003·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Ceinwen A Schreiner
Jul 23, 2003·Chemical Research in Toxicology·Stephen Safe, Mark Wormke
Mar 19, 2004·The Journal of Biological Chemistry·Daniel W NebertFrank J Gonzalez
Jan 22, 2005·Nature Reviews. Cancer·Andreas Luch
Mar 3, 2006·The Journal of Clinical Investigation·Bonnie J Deroo, Kenneth S Korach
Aug 1, 2006·Biochemical and Biophysical Research Communications·Mary Beth GenterDaniel W Nebert
Jul 7, 2007·Physiological Reviews·Nina HeldringJan-Ake Gustafsson
Jan 22, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jessica E S BohonowychMichael S Denison
Mar 7, 2008·Nature·Sara KangaspeskaGeorge Reid
Jul 12, 2008·Molecular Endocrinology·Zeynep Madak-ErdoganBenita S Katzenellenbogen
Mar 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Carrie Hayes SutterThomas R Sutter
Apr 23, 2009·Molecular Oncology·Nancy BretschneiderStefanie Denger
Jul 4, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Shaimaa AhmedJason Matthews
Sep 5, 2009·Journal of Agricultural and Food Chemistry·Maurus BiedermannKoni Grob
Dec 3, 2009·Molecular Endocrinology·Jamie Bonéy-MontoyaAnn M Nardulli
Feb 11, 2011·Environmental Toxicology and Chemistry·Cozmina M VrabieMichiel T O Jonker
Nov 14, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Joep BrinkmannAndreas Luch
Feb 15, 2013·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·R LorenziniI Braschi
Mar 26, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Patrick TarnowAndreas Luch
May 10, 2013·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Maurus BiedermannKoni Grob
Apr 24, 2014·Journal of Toxicology and Environmental Health. Part a·Iurgi SalaberriaBjørn Henrik Hansen

❮ Previous
Next ❯

Citations

Jul 6, 2016·Archives of Toxicology·M GleiW Schlörmann
Apr 6, 2017·Archives of Toxicology·Juliane SowadaTewes Tralau
Jan 16, 2019·Expert Opinion on Drug Metabolism & Toxicology·Patrick TarnowAndreas Luch
Jun 15, 2018·Reproduction, Fertility, and Development·C M ChristanteR M Góes
Sep 22, 2018·The Science of the Total Environment·Khajornsak SopajareeYu-Hsuan Yen
Jun 24, 2021·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Erica SelinJohan Lundqvist
Jan 21, 2020·Chemical Research in Toxicology·Patrick TarnowAndreas Luch

❮ Previous
Next ❯

Methods Mentioned

BETA
FCS
chemical treatment
electrophoresis
PCR

Software Mentioned

CometImager

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.