Estrogenic effects of Ficus umbellata Vahl. (Moraceae) extracts and their ability to alleviate some menopausal symptoms induced by ovariectomy in Wistar rats

Journal of Ethnopharmacology
Stéphane ZingueD Njamen

Abstract

Ficus umbellata Vahl. (Moraceae) is a medicinal plant used in Cameroon to treat amenorrhea as well as other physiological disorders related to menopause. In order to justify scientifically its traditional use, the estrogen-like properties of the aqueous (AE) and methanol (MeOH) extracts of F. umbellata were investigated. In vitro, the ability of different extracts of F. umbellata to activate estrogen receptors α (ERα) and β (ERβ) in cell-based reporter gene assays using human embryonic kidney (HEK293T) cells transfected with ERs was tested. In vivo, a 3-day uterotrophic assay and the capacity of the extracts to alleviate hot flushes in ovariectomized adult rats were tested. Using a bioassay-guided fractionation the major compound of F. umbellata was isolated and tested in vitro on HEK293T-ERα and ERβ cells. AE and MeOH extracts significantly altered ERα as well as ERβ activities. In vivo, both extracts significantly increase the uterine and vaginal epithelium thickness, and uterine total protein levels in a dose dependent manner. Interestingly, both extracts of F. umbellata at the dose of 100 mg/kg BW significantly decreased the total number, average duration as well as frequency of hot flushes in experimental rats compared to ...Continue Reading

References

Mar 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R L LipnickJ A Springer
May 12, 2001·European Journal of Pharmacology·H H BerendsenH J Kloosterboer
Jun 16, 2001·American Journal of Human Biology : the Official Journal of the Human Biology Council·R R Freedman
Mar 2, 2002·Fertility and Sterility·Robert R Freedman, Charla M Blacker
Aug 21, 2003·Lancet·Valerie Beral, UNKNOWN Million Women Study Collaborators
Sep 19, 2003·Phytotherapy Research : PTR·Andreana L Ososki, Edward J Kennelly
Dec 16, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nancy E LaneThomas J Wronski
Jul 10, 2004·Menopause : the Journal of the North American Menopause Society·Alessandra CrisafulliFrancesco Squadrito
May 4, 2005·Lancet·Valerie BeralUNKNOWN Million Women Study Collaborators
Feb 27, 2007·Journal of Chromatography. a·J Brent Friesen, Guido F Pauli
Jul 22, 2008·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Peter Nkwo, Hyacinth Onah
Aug 5, 2008·Clinical Obstetrics and Gynecology·Nanette Santoro
Jul 10, 2009·Women's Health·JoAnn V PinkertonRebecca S Kightlinger
Jul 12, 2011·European Journal of Pharmacology·Fausto Alejandro Jiménez-OrozcoJuan José Mandoki
Jan 1, 2010·Frontiers in Pharmacology·Victor Kuete, Thomas Efferth
Jan 10, 2012·Journal of Circadian Rhythms·Dorothee GirbigBernd-Wolfgang Igl
Mar 7, 2012·Menopause International·Joan Pitkin
Jan 1, 2011·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·C N Fokunang Kamsu-Kom
Feb 27, 2013·The Journal of Sexual Medicine·Maureen E BashaSamuel Chacko
Mar 30, 2013·Planta medica·Dieudonne NjamenGünter Vollmer
Aug 24, 2013·Journal of Complementary & Integrative Medicine·Dieudonné NjamenBenedicta N Nkeh-Chungag
Oct 1, 2013·Journal of Pharmacological Sciences·Stéphane ZingueChantal Beatrice Magne Nde
Jul 22, 2014·Magnetic Resonance in Chemistry : MRC·Celina Alvarez-CisnerosPedro Joseph-Nathan

❮ Previous
Next ❯

Citations

Mar 17, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yang YeShu-Ming Huang
Aug 5, 2017·BMC Complementary and Alternative Medicine·Stéphane ZingueDieudonné Njamen
Jan 23, 2017·BMC Complementary and Alternative Medicine·Stéphane ZingueDieudonné Njamen
May 27, 2017·International Journal of Molecular Sciences·Kevine Kamga SiliheTânia Beatriz Creczynski-Pasa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.