PMID: 9654651Jul 9, 1998Paper

Estrogenic effects of the synthetic aminoestrogen 17 beta-(5-hydroxy-1-pentylamino)-1,3,5(10)-estratrien-3-ol (pentolame)

Steroids
A E LemusF Larrea

Abstract

In this study, we investigated the effects of pentolame, a 17 beta-aminoestrogen derivative, upon coagulation, serum LH, pituitary progestin receptors, uterine weight, and endometrium morphological changes in the castrated female rat. Groups of animals were subcutaneously (s.c.) injected with either estradiol (E2) (0.1 up to 1000 micrograms/animal), pentolame (1 up to 1000 micrograms/animal), or the vehicle alone daily for 5 consecutive days starting 2 weeks following ovariectomy. Administration of pentolame (10 to 1000 micrograms/animal) increased significantly (p < 0.05) the blood clotting time when compared with that obtained in the group of control animals (EC50 582 micrograms). Pentolame (500 and 1000 micrograms/rat for 5 days) caused a significant inhibition (p < 0.01) of serum LH levels (IC50 860 micrograms), which remained suppressed until Day 5 post last injection. In addition, treatment with pentolame was able to restore in the castrated female rat the presence of specific estrogen-dependent progestin binding sites at the anterior pituitary level. The affinity constants and the number of binding sites of pentolame-induced progestin receptors were similar to those obtained with estradiol at equipotent doses (860 microg...Continue Reading

References

Jan 1, 1985·Journal of Steroid Biochemistry·B A ChávezG Pérez-Palacios
Apr 1, 1984·Journal of Steroid Biochemistry·F LarreaG Pérez-Palacios
Jun 12, 1995·Annals of the New York Academy of Sciences·D P McDonnellR B Stein
Dec 1, 1993·Journal of Clinical Pharmacology·D P McDonnellM A Gleeson

❮ Previous
Next ❯

Citations

Mar 15, 2005·European Journal of Pharmacology·Cristina LeminiRuth Jaimez
Mar 15, 2005·European Journal of Pharmacology·Cristina LeminiRuth Jaimez
Aug 30, 2011·Steroids·María Guadalupe Hernández-LinaresGabriel Guerrero-Luna
Apr 23, 2009·Physiology & Behavior·C Lemini, E Canchola
Aug 5, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·C LeminiL Martínez-Mota
Apr 13, 2011·European Journal of Medicinal Chemistry·Angélica RayaCatalina Soriano-Correa
Jan 12, 2013·European Journal of Pharmacology·Cristina LeminiAna Elena Lemus
Dec 3, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Cristina LeminiFernando Larrea
Sep 18, 2016·Basic & Clinical Pharmacology & Toxicology·Cristina LeminiAlejandro Jiménez-Orozco
Oct 15, 2014·Experimental Animals·Cristina LeminiMartha Medina

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.