Estrogenic Impact on Cardiac Ischemic/Reperfusion Injury

Journal of Cardiovascular Translational Research
Sivaporn SivasinprasasnNipon Chattipakorn

Abstract

The increase in cardiovascular disease and metabolic syndrome incidence following the onset of menopause has highlighted the role of estrogen as a cardiometabolic protective agent. Specifically regarding the heart, estrogen induced an improvement in cardiac function, preserved calcium homeostasis, and inhibited the mitochondrial apoptotic pathway. The beneficial effects of estrogen in relation to cardiac ischemia/reperfusion (I/R) injury, such as reduced infarction and ameliorated post-ischemic recovery, have also been shown. Nevertheless, controversial findings exist and estrogen therapy is reported to be related to a higher rate of thromboembolic events and atrial fibrillation in post-menopausal women. Therefore, greater clarification is needed to evaluate the exact potential of estrogen use in cases of cardiac I/R injury. This article reviews the effects of estrogen, in both acute and chronic treatment, and collates the studies with regard to their in vivo, in vitro, or clinical trial settings in cases of cardiac I/R injury and myocardial infarction.

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Citations

Mar 16, 2017·Menopause : the Journal of the North American Menopause Society·Wasana PratchayasakulSiriporn C Chattipakorn
Aug 23, 2018·Journal of Cellular Physiology·Manman XuJun Wang
Jun 1, 2021·Frontiers in Physiology·Giulia QuerioClaudia Penna

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