Estrogenicity of novel phase I and phase II metabolites of zearalenone and cis-zearalenone

Toxicon : Official Journal of the International Society on Toxinology
Sarah S DrzymalaMatthias Koch

Abstract

Zearalenone and its cis-isomer, cis-zearalenone, are nonsteroidal mycotoxins that elicit an estrogenic response upon binding to the estrogen receptor. This study compares the estrogenicity of eleven congeners including novel metabolites as 15-OH-zearalenone, zearalenone-14-sulfate, α-cis-zearalenol and β-cis-zearalenol using the E-Screen assay. Overall, a change in the configuration from trans to cis retains significant estrogenic activity. In contrast, alterations of the aromatic moiety including hydroxylation and sulfation showed a markedly decreased estrogenicity when compared to zearalenone.

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Citations

Jan 23, 2016·Toxicon : Official Journal of the International Society on Toxinology·Luca DellafioraChiara Dall'Asta
Aug 18, 2016·Toxicon : Official Journal of the International Society on Toxinology·Jian JiXiulan Sun
Apr 21, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marcin BryłaRenata Jędrzejczak
Aug 27, 2019·Critical Reviews in Food Science and Nutrition·Ankita RaiAnurag Tripathi
Oct 17, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Julia KellerMatthias Koch
Feb 11, 2020·Frontiers in Veterinary Science·Carrie K VanceNancy W Shappell
Jul 31, 2017·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Isabelle P Oswald
Feb 18, 2017·Toxins·Sabina B BinderFranz Berthiller
Jun 28, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hans SteinkellnerJan Alexander
Nov 15, 2020·Analytical Methods : Advancing Methods and Applications·Xinyi MaoGuoqing Shi
Sep 1, 2018·Comprehensive Reviews in Food Science and Food Safety·Arnau VidalMarthe De Boevre
Apr 21, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Fojan AgahiCristina Juan
Aug 12, 2021·Animal Nutrition·Kuntan WuShuai Wang

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