PMID: 11907937Mar 23, 2002Paper

Estrogens and the cardiovascular system: role of estradiol metabolites in hormone replacement therapy

Climacteric : the Journal of the International Menopause Society
T H LippertA O Mueck

Abstract

Estrogen substitution in the postmenopause reduces cardiovascular disease by means of direct and indirect effects of estradiol on the cardiovascular system. Recently, there have been increased indications that estradiol metabolites can also have beneficial effects. In the present short review, the existing experimental data for effects of estradiol metabolites on the blood vessels have been compiled. Results of our own studies, together with those of other research groups, indicate that particularly the catechol estrogens are able to exert a positive influence on the cardiovascular system, and may perhaps play a physiological role there. Attention is drawn to clinical-pharmacological aspects for use of estradiol metabolites for the prevention and treatment of cardiovascular disease.

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Citations

Jul 19, 2000·Steroids·T H LippertA O Mueck
Sep 25, 2002·Maturitas·Alfred O MueckTheodor H Lippert
Aug 23, 2006·Clinical and Experimental Pharmacology & Physiology·Hui-Ping WangQiang Xia
Jul 1, 2007·Women's Health·Alessandra Graziottin
Jul 13, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Alfred O Mueck, Harald Seeger
Jul 30, 2014·Climacteric : the Journal of the International Menopause Society·X Ruan, A O Mueck
Apr 21, 2006·Brain Research Bulletin·David O EddingtonT J Wu
Jan 1, 2010·Hormone Molecular Biology and Clinical Investigation·Harald Seeger, Alfred O Mueck

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