Estrogens can contribute to hydrogen peroxide generation and quinone-mediated DNA damage in peripheral blood lymphocytes from patients with vitiligo

The Journal of Investigative Dermatology
Karin U SchallreuterDiana Anderson

Abstract

To date there is ample in vivo and in vitro evidence for increased epidermal and systemic hydrogen peroxide (H(2)O(2)) levels in vitiligo, which can be reduced with a topical application of a pseudocatalase-K.U. Schallreuter (PC-KUS) leading to the recovery of epidermal catalase levels as well as other enzymes in peripheral blood cells. Recently, the generation of H(2)O(2) by oxidative metabolism of estrogens and other aromatic steroids was documented. Therefore, it was tempting to follow estrogen-generated H(2)O(2) and its possible effect on DNA damage in peripheral blood lymphocytes from patients with vitiligo before and after the reduction of epidermal H(2)O(2) with pseudocatalase PC-KUS compared to controls. For this purpose, 20 Caucasian patients were grouped in treated responders (group A, n=11) and untreated active/acute disease (group B, n=9) and compared to Caucasian healthy controls (group C, n=7). Consequently, epidermal catalase protein expression in full skin biopsies was assessed using immunofluorescence labelling together with determination of basal H(2)O(2) levels in peripheral blood lymphocytes. To test the influence of estrogen on H(2)O(2) generation and DNA damage, freshly prepared peripheral blood lymphocyte...Continue Reading

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Citations

May 23, 2012·The New England Journal of Medicine·Sanjay H ChotirmallNoel G McElvaney
Jan 20, 2007·The Journal of Investigative Dermatology·Maria Lucia Dell'AnnaMauro Picardo
Oct 19, 2007·The Journal of Investigative Dermatology·Karin U SchallreuterJohn M Wood
Nov 13, 2007·Free Radical Biology & Medicine·Karin U SchallreuterJohn M Wood
Mar 6, 2007·Life Sciences·Karin U Schallreuter, Souna Elwary
Apr 20, 2007·The British Journal of Dermatology·K U Schallreuter, H Rokos
Sep 14, 2007·Pigment Cell Research·Wiete Westerhof, Marco d'Ischia
Jul 11, 2008·International Journal of Dermatology·Karin U SchallreuterJohn M Wood
Aug 21, 2013·The British Journal of Dermatology·K U Schallreuter
Oct 21, 2010·Clinical Science·Steven J Glassman
Apr 4, 2007·Archives of Dermatological Research·Karin U SchallreuterAngela Panske
Jan 18, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·R SpeeckaertN van Geel
Jun 24, 2009·Archives of Dermatological Research·L J LubakiM Heenen
Mar 6, 2010·Archives of Dermatological Research·K AroniE Patsouris
May 13, 2010·Bioscience, Biotechnology, and Biochemistry·Francis Garcia-MolinaJoseph Neptune Rodriguez-Lopez
Jun 16, 2010·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·K U Schallreuter, M M A E L Salem
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Oct 22, 2008·International Journal of Dermatology·Kyriaki AroniEfstratios S Patsouris
Jun 21, 2018·Frontiers in Endocrinology·Mohamed-I Kotb El-SayedRefaat R Mohamed
Jan 25, 2011·Experimental Dermatology·Wiete WesterhofMarco d'Ischia
Dec 13, 2019·Oxidative Medicine and Cellular Longevity·Ankita NandiNilanjana Das
Jan 2, 2021·International Journal of Molecular Sciences·Asako YamamotoIchiro Katayama
Oct 24, 2020·Scientific Reports·Wei LiuDong-Lai Ma

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