PMID: 16638600Apr 28, 2006Paper

Estrogens contribute to a sex difference in plasma potassium concentration: a mechanism for regulation of adrenal angiotensin receptors

Gender Medicine
Wei ZhengDarren M Roesch

Abstract

The adrenal mineralocorticoid aldosterone promotes sodium (Na(+)) reabsorption and potassium (K(+)) loss from the kidney. Female sex steroids such as estrogen and progesterone are known modulators of the renin-angiotensin-aldosterone system. We conducted studies to determine if there is a sex difference in plasma Na(+) concentration ([Na(+)]) and plasma K(+) concentration ([K(+)]), and if interactions between female sex steroids and aldosterone contribute to a sex difference in these electrolytes. Plasma [Na(+)] and [K(-)] were determined in weight-matched male and female Sprague-Dawley rats using an ion-selective electrode system. To assess the sensitivity of males and females to aldosterone, the mineralocorticoid was infused chronically by osmotic minipump. The role of female sex steroids in the regulation of plasma electrolyte concentrations was determined in bilaterally ovariectomized (OVX) female rats treated daily with SC injections of progesterone, 17beta-estradiol (E(2)), or selective estrogen receptor (ER) modulators. The role of plasma [K(+)] in the regulation of adrenal angiotensin II type 1 receptor (AT(1)R) expression was determined by manipulating plasma [K(+)] by varying dietary K(-). Adrenal AT(1)R expression wa...Continue Reading

References

Feb 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·G AguileraK J Catt
Nov 20, 1990·The Journal of Steroid Biochemistry and Molecular Biology·E E Baulieu, P Robel
Feb 15, 1984·American Journal of Obstetrics and Gynecology·C R Rosenfeld, G M Jackson
Apr 1, 1996·Steroids·E P Gómez-SánchezC E Gomez-Sanchez
Jul 1, 1997·Journal of Hypertension·K B BrosnihanC M Ferrario
Aug 13, 1998·The New England Journal of Medicine·F J Gennari
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·G H KimM A Knepper
Jan 20, 1999·Kidney International·J A MillerD C Cattran
Feb 4, 1999·Hypertension·P E GallagherK B Brosnihan

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Citations

Jan 19, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Miriam R BerryFiona E Karet Frankl
Aug 1, 2011·Therapeutic Advances in Endocrinology and Metabolism·Muhammad Adil Abbas KhanMark Gorman
Dec 30, 2011·Kidney International·Vicente E TorresUNKNOWN HALT PKD Study Group
Mar 14, 2012·Steroids·Vinciane Saint-CriqBrian J Harvey
May 6, 2011·Medical Hypotheses·Soha NamaziHamed Abedtash
Jul 18, 2017·Experimental Physiology·Jessica Santollo
Feb 16, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Hyung Woo KimUNKNOWN KNOW-CKD Study Investigators
Apr 27, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Feng LiMaureen Keller-Wood
Jul 21, 2007·Nephron. Physiology·Warren ThomasBrian J Harvey
May 30, 2014·Physiological Reports·Yamil R YusefBrian J Harvey
Apr 8, 2020·JCI Insight·Rolando Carrisoza-GaytanThomas R Kleyman
Apr 24, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Hong JiKathryn Sandberg
Jun 2, 2020·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Kuniya AsaiWataru Shimizu
Jun 3, 2021·International Journal of Molecular Sciences·Margaux LaulhéLaetitia Martinerie
Jan 22, 2022·British Journal of Clinical Pharmacology·Emiel LeegwaterLoes E Visser

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