PMID: 6540183Jun 1, 1984Paper

Estrone-induced, prolactin-secreting and dopamine-sensitive rat pituitary tumor

European Journal of Cancer & Clinical Oncology
M LisR Collu

Abstract

Prolactin (PRL)-secreting rat pituitary tumors were induced in female Fisher 344/Lis rats by s.c. implants of estrone (E1) pellets. Tumor growth was relatively fast and reached about 100 mg within 2 months. Ovariectomy at the time of E1 implants seemed to accelerate the growth of the tumors. Tumor cells in primary culture produced mainly PRL, while growth hormone (GH) release was about 2% of PRL production and the release of some other pituitary hormones did not exceed 1% of PRL values. Tumor cells were found to have high-affinity dopamine (DA) receptors. The addition of DA in vitro at 10(-10) M concentration stimulated PRL release, while at 10(-6) M concentration it inhibited the release of the hormone by more than 50% of control values. Histological, immunohistochemical and electron microscopical studies demonstrated the tumor to be composed mainly of maximally stimulated mammotrophs.

References

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Dec 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M E LiebermanJ Gorski
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Citations

Feb 1, 1989·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·T L RissD A Sirbasku
Jun 1, 1991·Molecular and Cellular Endocrinology·C BouvierR Collu
Aug 1, 1994·Journal of Neuroendocrinology·J C PainsonR Collu
Jan 1, 1993·Acta neurochirurgica·B AçikgözM Sumnu

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