Estrus variation in anticonflict effects of midazolam microinjected into septal nuclei in female Wistar rats

Pharmacology, Biochemistry, and Behavior
Miguel Molina-Hernandez, Norma Patricia Tellez-Alcántara

Abstract

Effects of midazolam intraperitoneally (3.0 mg/kg) administered, or locally applied into lateral septal nuclei (10 microg/microl), or into the medial septum (10 microg/microl) were assessed in Wistar rats during late proestrus or metestrus-diestrus in a conflict-operant task. A reduction in conflict behavior was found in control rats during late proestrus (P<.05), when compared to metestrus-diestrus. Systemic injections of midazolam (P<.05) or midazolam infusions into lateral septal nuclei (P<.05) also reduced conflict behavior only during late proestrus, whereas midazolam infusions into the medial septum produced neither of these anticonflict effects in any estrous phase. In conclusion, an endocrine-related variation in anticonflict effects of midazolam microinjected into lateral septal nuclei was displayed by female rats.

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Citations

Jul 23, 2003·Pharmacology, Biochemistry, and Behavior·M Molina-HernándezM Teresa Jaramillo
Oct 9, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Miguel Molina-HernandezJorge Ivan Olivera Lopez
Jul 28, 2009·Psychoneuroendocrinology·Jamie Maguire, Istvan Mody
Jul 15, 2015·Reviews in the Neurosciences·Anjana Bali, Amteshwar Singh Jaggi
Jun 9, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Miguel Molina-HernándezM Teresa Jaramillo
Dec 1, 2010·Behavioural Brain Research·Ana M BassoLynne E Rueter
Sep 13, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Miguel Molina-HernándezM Teresa Jaramillo
Nov 15, 2012·Pharmacology, Biochemistry, and Behavior·Miguel Molina-HernándezM Teresa Jaramillo
Mar 31, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alicia A Walf, Cheryl A Frye

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