Abstract
The major Mycobacterium tuberculosis virulence factor ESAT-6 exported by the ESX-1 secretion system has been described as a pro-apoptotic factor by several independent groups in recent years, sustaining a role for apoptosis in M. tuberculosis pathogenesis. This role has been supported by independent studies in which apoptosis has been shown as a hallmark feature in human and mouse lungs infected with virulent strains. Nevertheless, the role of apoptosis during mycobacterial infection is subject to an intense debate. Several works maintain that apoptosis is more evident with attenuated strains, whereas virulent mycobacteria tend to inhibit this process, suggesting that apoptosis induction may be a host mechanism to control infection. In this review, we summarize the evidences that support the involvement of ESX-1-induced apoptosis in virulence, intending to provide a rational treatise for the role of programmed cell death during M. tuberculosis infection.
Citations
Feb 9, 2016·Developmental and Comparative Immunology·Xinhua HuangDecheng Wang
Nov 26, 2015·Virulence·Lia DanelishviliLuiz E Bermudez
Feb 24, 2015·Immunological Reviews·Günter Weiss, Ulrich E Schaible
Oct 21, 2015·Frontiers in Immunology·Andrea CruzAntónio G Castro
Jun 30, 2015·Future Microbiology·Giovanni DeloguRiccardo Manganelli
Dec 3, 2014·Seminars in Immunology·Marilena Paola EtnaEliana Marina Coccia
Dec 30, 2014·Frontiers in Cellular and Infection Microbiology·Ainhoa ArbuesCatherine Astarie-Dequeker
Jul 6, 2014·Frontiers in Cellular and Infection Microbiology·Yongqun He, Amal O Amer
Jan 18, 2017·Cellular Microbiology·Jacques AugenstreichCatherine Astarie-Dequeker
Jan 13, 2018·Frontiers in Immunology·Jesus Gonzalo-AsensioNacho Aguilo
Jul 25, 2017·Parasitology·Rajeev RaiGiulia Getti
Aug 25, 2017·Cell Death & Disease·Jake WhangHwa-Jung Kim
Dec 30, 2014·Apoptosis : an International Journal on Programmed Cell Death·Yun-Ji LimChang-Hwa Song
Apr 5, 2015·Apoptosis : an International Journal on Programmed Cell Death·Minqiang LiuJianping Xie
Jun 3, 2015·Cellular Microbiology·Bhavana TiwariTirumalai R Raghunand
Jan 30, 2018·Frontiers in Cellular and Infection Microbiology·Elena Cardenal-MuñozThierry Soldati
Mar 27, 2019·Molecular and Cellular Biochemistry·Jiahui LinYalei Dai
Dec 27, 2016·Frontiers in Cellular and Infection Microbiology·Yongyong CuiXiangmei Zhou
Aug 7, 2019·Microbiology Insights·Jessica Gräb, Jan Rybniker
Oct 13, 2020·Frontiers in Cellular and Infection Microbiology·Tarina SharmaSeyed Ehtesham Hasnain
Dec 9, 2020·Emerging Microbes & Infections·Qinglong GuoXuelian Zhang
Dec 29, 2020·Virulence·Cecilia B KorolAdrian M Zelazny
Jul 16, 2017·Microbiology Spectrum·Jesus Gonzalo-AsensioCarlos Martin