ET-1 plasma levels and ocular blood flow in retinitis pigmentosa

Canadian Journal of Physiology and Pharmacology
Mauro CelliniEmilio C Campos

Abstract

Retinitis pigmentosa (RP) is an inherited retinal disorder clinically characterized by a pale, waxy optic nerve head, attenuated retinal blood vessels, and bone spicule pigment in the retina. Hemodynamic studies have demonstrated that RP is associated with a reduction in the retinal and choroidal blood flow. Retinal hemodynamic impairment is also present in early stages of RP, and various hypotheses have been advanced as to the cause. The authors studied 20 patients, 12 males and 8 females, aged 26-42 years (mean 35.1 years) and affected by simplex RP. The patients had a visual acuity of 0.9 +/- 0.1, visual field mean defect of -6.52 +/- 3.58 dB, and b-wave electroretinogram amplitude of 260.08 +/- 8.24 microV. An increase in plasma levels of endothelin-1 (ET-1) was found: 1.910 +/- 0.317 pg/mL versus 1.180 +/- 0.210 pg/mL in non-RP controls (p < 0.02). Moreover both an ocular and systemic vascular impairment was detected by means of color Doppler imaging and laser Doppler flowmetry performed during a cold pressor test. We found a correlation between the increase of ET-1 plasma levels in RP and the decrease of peak systolic velocity in the ophthalmic artery (p < 0.03) and in the posterior ciliary arteries (p < 0.006). It is tho...Continue Reading

References

Mar 1, 1976·Survey of Ophthalmology·S Merin, E Auerbach
Apr 1, 1992·Current Eye Research·E GranstamA Bill
May 1, 1991·Archives of Ophthalmology·M W MacCumberS H Snyder
Nov 1, 1991·Klinische Monatsblätter für Augenheilkunde·S WolfM Reim
Oct 13, 1991·The New England Journal of Medicine·A LermanJ C Burnett
Sep 1, 1990·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M S Simonson, M J Dunn
Jun 1, 1990·The American Journal of Medicine·M KohnoT Takeda
May 1, 1990·Diabetologia·K TakahashiS R Bloom
Sep 1, 1989·Experimental Eye Research·C J PournarasK Strommer
Nov 1, 1993·Experimental Eye Research·P CholletJ Plouet
Oct 1, 1996·American Journal of Ophthalmology·J E GrunwaldJ Dupont
Jan 1, 1956·The British Journal of Ophthalmology·D R LUCAS
Jun 9, 2004·Experimental Eye Research·Santosh NarayanThomas Yorio
Nov 24, 2005·Investigative Ophthalmology & Visual Science·Takatoshi KobayashiTsunehiko Ikeda
Jun 3, 2008·Canadian Journal of Physiology and Pharmacology·Raghu R KrishnamoorthyThomas Yorio

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Citations

Sep 27, 2013·PloS One·Cristina Martínez-Fernández de la CámaraRegina Rodrigo
May 9, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yao ZongQianying Gao
Jul 3, 2015·Journal of Ophthalmology·Ernesto StrobbeEmilio C Campos
Nov 28, 2015·Journal of Ophthalmology·Francesco Saverio SorrentinoPaolo Perri
Dec 4, 2012·The EPMA Journal·Katarzyna KonieczkaJosef Flammer
Aug 28, 2014·Retina·Almutez M GharaibehMuawyah D Albdour
Dec 7, 2017·The EPMA Journal·Katarzyna Konieczka, Carl Erb
Apr 16, 2018·Ophthalmic Research·Xiao Na WangXiao Yan Peng
Apr 29, 2014·Acta Ophthalmologica·Thor EysteinssonEinar Stefánsson
Jun 28, 2016·The British Journal of Ophthalmology·Maurizio Battaglia ParodiFrancesco Bandello
May 18, 2019·Acta Ophthalmologica·Matt LangAlice C Verticchio Vercellin
May 21, 2014·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Jay ChhablaniIgor Kozak
Mar 8, 2016·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Jay ChhablaniSubhadra Jalali
Feb 6, 2016·Vestnik oftalmologii·T N KiselevaS Yu Rogova
Jul 21, 2017·The EPMA Journal·Tilo BlechschmidtMargarita G Todorova
Apr 30, 2014·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Ava K BittnerGislin Dagnelie
Sep 5, 2018·Scientific Reports·Ruben JaureguiStephen H Tsang
Nov 2, 2019·Investigative Ophthalmology & Visual Science·Rui LinZi-Bing Jin
Jun 1, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sally S OngMandeep S Singh
Sep 30, 2021·Seminars in Ophthalmology·Alper Can YilmazUmut Karaca

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