ETA and ETB receptors contribute to neuropeptide Y-induced secretion of endothelin-1 in right but not left human ventricular endocardial endothelial cells

Neuropeptides
Dima Abdel-SamadDanielle Jacques

Abstract

Our recent work showed that neuropeptide Y-induced secretion of endothelin-1 (ET-1) in left and right human ventricular endocardial endothelial cells (hLEECs or hREECs respectively) via the activation of neuropeptide Y2 or Y5 receptors depending on the cell type. The aim of this study was to verify whether hLEECs or hREECs secretion of ET-1 induced by NPY is due, in part, to the activation of ETA and/or ETB receptors by the secreted ET-1. Using the technique of indirect immunofluorescence coupled to real 3-D confocal microscopy, as well as ELISA, our results show that in hREECs, the NPY-induced release of ET-1 seems to be due, in part, to the activation of both ETA and ETB receptors. On the other hand, in hLEECs, ETA and ETB receptors do not contribute to the ET-1 released by NPY. Therefore, our results suggest that the NPY-induced release of ET-1 in EECRs is due to NPY receptor activation and the subsequent activation of the ETA and ETB receptors by the released ET-1. However, the release of ET-1 by NPY in hLEECs is mainly due to NPY receptor activation. Furthermore, this secretory process of ET-1 is different between the right and left ventricular cells and highlights the important tuning roles that right and left ventricular...Continue Reading

References

Apr 14, 1989·Biochemical and Biophysical Research Communications·T EmoriF Marumo
Aug 18, 1993·Biochimica Et Biophysica Acta·B H ChuaB B Siu
Nov 1, 1996·Progress in Cardiovascular Diseases·A M ShahW J Paulus
May 19, 1998·Trends in Pharmacological Sciences·L A Selbie, S J Hill
Nov 15, 2000·Journal of Cardiovascular Pharmacology·D JacquesD Charest
Sep 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Dan HoangThomas C Westfall
May 8, 2003·Canadian Journal of Physiology and Pharmacology·Danielle JacquesClaudine Perreault
Feb 7, 2006·Pharmacology & Therapeutics·Friedrich BrunnerAdelino F Leite-Moreira
Jan 16, 2007·Peptides·Dima Abdel-SamadChantal Provost
Nov 19, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ghassan BkailyDanielle Jacques
Jul 13, 2012·Canadian Journal of Physiology and Pharmacology·Ghassan BkailyDanielle Jacques
Feb 27, 2014·Current Vascular Pharmacology·Ghassan BkailyDanielle Jacques

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Citations

Mar 22, 2019·Canadian Journal of Physiology and Pharmacology·Marc ChamounGhassan Bkaily
Jul 25, 2017·Canadian Journal of Physiology and Pharmacology·Danielle JacquesGhassan Bkaily
Jul 22, 2017·Canadian Journal of Physiology and Pharmacology·Marianne MikhailGhassan Bkaily
Feb 8, 2019·Canadian Journal of Physiology and Pharmacology·Danielle JacquesGhassan Bkaily
May 21, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Dennis K Lee, Ori Nevo

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