PMID: 8587384Jan 1, 1995Paper

ETA receptors predominate in the human vasculature and mediate constriction

Journal of Cardiovascular Pharmacology
A P DavenportS P Harland

Abstract

Our aim was to identify which endothelin (ET) receptor subtypes are present in the human vasculature. We used subtype-selective radiolabeled ligands, [125I]-PD151242 and [125I]-BQ3020, to measure the ratio of endothelin ETA and ETB receptors in the media of blood vessels in human tissues including brain, kidney, heart, lung, and adrenal. In the brain, resistance vessels (diameter less than 300 micron) within the cortex and the pial arteries expressed only ETA receptors. In the kidney, high densities of ETA receptors were localized to the resistance vessels. A small population of ETB receptors was detectable in larger diameter vessels; the ratios of ETA: ETB were 90:10 (renal artery), 92:8 (renal vein), and 95:5 (arcuate artery). In the heart, only ETA receptors could be detected within intramyocardial resistance vessels. A small number of ETB receptors (less than 15%) were found in epicardial coronary arteries and aorta removed from patients with atherosclerosis, but ETB receptors were difficult to detect in normal vessels. In the adrenal, ETA receptors also predominated in arteries of the capsular plexus (87:13), central medullary vein (85:15), and resistance vessels. ETB receptors also represented less than 15% of the ET rece...Continue Reading

Citations

Jan 13, 2001·British Journal of Pharmacology·K E Wiley, A P Davenport
Jan 23, 2013·The American Journal of Chinese Medicine·Chih-Ying ChenLo-Chun Au
May 13, 2015·Seminars in Nephrology·Zhengrong GuanEdward W Inscho
Mar 26, 1998·Experimental Neurology·F CrawfordM Mullan
May 29, 2007·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Ke-Jing HuangHong Wang
Dec 1, 2001·Biological & Pharmaceutical Bulletin·K Goto
Jan 16, 2002·Current Hypertension Reports·David HürlimannFrank Ruschitzka
May 10, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Jean-Claude HonoréPedro D'Orleans-Juste
Feb 23, 2011·The Open Cardiovascular Medicine Journal·Aamer SandooGeorge D Kitas
Jan 31, 2020·Physiological Reviews·Jens Leipziger, Helle Praetorius
Mar 10, 2016·Pharmacological Reviews·Anthony P DavenportJanet J Maguire

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