Etanercept or Methotrexate Withdrawal in Rheumatoid Arthritis Patients in Sustained Remission.

Arthritis & Rheumatology
Jeffrey R CurtisJames Chung

Abstract

Patients with rheumatoid arthritis (RA) in whom remission is achieved following combination therapy with methotrexate plus etanercept face an ongoing medication burden. This study was undertaken to investigate whether sustained remission achieved on combination therapy can be maintained with either methotrexate or etanercept monotherapy, as assessed following discontinuation of one or the other medication from the combination. Of the 371 adult patients with RA who received combination therapy with methotrexate plus etanercept, remission (defined as a Simplified Disease Activity Index [SDAI] score of ≤3.3) was sustained in 253 patients through a 24-week open-label period. These 253 patients then entered a 48-week, double-blind period and were randomized to receive either 1) methotrexate monotherapy (n = 101), 2) etanercept monotherapy (n = 101), or 3) methotrexate plus etanercept combination therapy (n = 51). Patients who subsequently experienced disease-worsening received rescue therapy with the combination regimen at the same dosages as used in the initial run-in period. The primary end point was the proportion of patients in whom SDAI-defined remission was maintained without disease-worsening at week 48 in the etanercept mono...Continue Reading

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Citations

Dec 4, 2020·Nature Reviews. Rheumatology·Sarah Onuora
Jul 13, 2021·ACR Open Rheumatology·Can M Sungur
Jul 18, 2021·Nature Reviews. Rheumatology·Rieke Alten, Max Mischkewitz

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