Etanercept therapy allows the tapering of methotrexate and sustained clinical responses in patients with moderate to severe psoriasis

International Journal of Dermatology
Paul S Yamauchi, Nicholas J Lowe

Abstract

Methotrexate, the most common systemic small molecule used in the treatment of moderate to severe psoriasis, is associated with significant toxicities and adverse events. Long-term continuous usage is not recommended due to potential liver toxicity, myelosuppression, and other side effects. Abrupt cessation of methotrexate without tapering can lead to flare-up and rebound of psoriasis. Here we describe sustained clinical responses in 6 patients with psoriasis following gradual cessation of methotrexate through the addition of etanercept therapy.

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Sep 24, 2004·Dermatologic Therapy·William G Stebbins, Mark G Lebwohl

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Citations

Nov 7, 2014·American Journal of Clinical Dermatology·Jennifer C Cather, Jeffrey J Crowley
Apr 25, 2009·Journal of the American Academy of Dermatology·Robert E KalbMark Lebwohl
Mar 27, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·P A FoleyA J Cooper
Jul 11, 2013·Clinical and Experimental Dermatology·S Dogra, R Mahajan
Apr 14, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·C AntoniouA Katsambas
Dec 23, 2014·Actas dermo-sifiliográficas·M AraE Pastushenko
Mar 21, 2009·Journal of Cutaneous Medicine and Surgery·Efstathios RallisMarkos Papaconstantis
Jan 28, 2020·Expert Opinion on Drug Safety·Mio Nakamura, John Koo
Nov 1, 2016·The Australasian Journal of Dermatology·Carlos Muñoz-SantosAntonio Guilabert

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