PMID: 8587389Jan 1, 1995Paper

ETB receptors promote proliferation and migration of endothelial cells

Journal of Cardiovascular Pharmacology
M ZicheF Ledda

Abstract

We investigated endothelin-1 and -3 (ET-1, ET-3) effects on proliferation and migration of endothelial cells isolated from bovine adrenal capillaries (BACEs) and from human umbilical veins (HUVECs). Dose-dependent proliferation was produced by ET-1 and ET-3 in both cell lines, with maximal effects at 0.1 nM concentration. ET-1 and ET-3 also stimulated BACE and HUVEC mobilization in a dose-dependent manner. The selective agonist for the ETB receptor ET(16-21) showed the same effects as ET-1 and ET-3 on proliferation and migration in both cell lines. The ETB receptor antagonist IRL 1038 (1 microM) blocked the migration induced by both ET-3 and ET[16-21], whereas the ETA receptor antagonist BQ 123 (1 microM) was ineffective. We conclude that endothelins, by favoring endothelial cell growth and mobilization, can contribute to neovascularization through an autocrine mechanism that requires ETB receptor activation.

Citations

Dec 21, 2000·International Journal of Cardiology·Y TanakaY Mitsui
Jul 2, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lana E KandalaftGeorge Coukos
Apr 18, 1998·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·E H AshamI Taylor
Dec 12, 2002·Trends in Endocrinology and Metabolism : TEM·Anna Bagnato, Francesca Spinella
Jun 10, 2000·British Journal of Clinical Pharmacology·M C VerhaarT J Rabelink
Apr 25, 2013·Cytokine & Growth Factor Reviews·Shek Man ChimJiake Xu
Jan 5, 2002·Cancer Investigation·B ArunT Gokaslan
Jan 28, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Arianna PalladiniPatrizia Nanni
Oct 13, 2005·Pharmacology & Therapeutics·Sophie MotteRobert Naeije
Dec 7, 2000·The American Journal of Pathology·G EgidyF Pinet
Jul 1, 1997·Journal of Vascular Surgery·D A BarberV M Miller
Mar 27, 2007·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·L G PedersenL H Olsen

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