Ethambutol-related impaired visual function in childrens less than 5 years of age treated for a mycobacterial infection: diagnosis and evolution

The Pediatric Infectious Disease Journal
Michael LevyAlbert Faye

Abstract

The effects of ethambutol (EMB) on vision are particularly difficult to detect in children less than 5 years of age because of a lack of complaints and objective clinical signs. The aim of this study was to assess the frequency of visual abnormalities and the utility of visual-evoked potentials (VEPs) recordings in monitoring the visual function of children less than 5 years of age who were exposed to EMB during anti-mycobacterial treatment. We performed a retrospective study in Robert-Debré University Hospital, Paris, France, including all children less than 5 years of age, who were treated with EMB for a mycobacterial infection from January 2002 to December 2012. Fourteen patients were enrolled, including 12 treated for Mycobacterium tuberculosis infection. The sex ratio was 1:1. The median age was 1.65 years (0.3 to 4.7). Five patients had subarachnoid involvement. The median EMB dose was 22 mg/kg/day (15 to 27). Only 11 patients were monitored using VEPs. Three children (27.3%) developed a visual impairment secondary to EMB, with delays of 4, 7 and 36 weeks. One of the 3 patients developed an impairment of the retrochiasmatic visual pathways, and 2 other patients developed classical retrobulbar optic neuritis. In all cases,...Continue Reading

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Citations

Sep 15, 2015·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·Roi Piñeiro PérezUNKNOWN en representación de pTBred (Red Española de Estudio de Tuberculosis Pediátrica)
Dec 19, 2016·Revista Portuguesa De Pneumologia·L FigueiraR Duarte
Jan 1, 2015·Journal of the International AIDS Society·Mary-Ann DaviesMarlène Bras
Dec 8, 2015·Journal of the International AIDS Society·Helena RabieAnthony J Garcia-Prats
Nov 28, 2015·Paediatric Drugs·Nicola PrincipiUNKNOWN Italian Pediatric TB Study Group

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