Ethanol abolishes ischemic preconditioning in humans

Journal of the American College of Cardiology
Giampaolo NiccoliFilippo Crea

Abstract

This study sought to assess the effect of acute alcohol intake on ischemic preconditioning (IPC) in humans using the clinical model of 2 sequential balloon inflations during a percutaneous coronary intervention (PCI). Ischemic preconditioning is the most potent form of endogenous myocardial protection from irreversible ischemic injury. Experimental observations suggest that acute ethanol administration might abolish IPC. We studied 30 consecutive patients (22 men, mean age 65 years) undergoing elective coronary angioplasty who were randomized to receive an oral dose of 40 g ethylic alcohol (administered as 149 ml of Gordon's Gin) or 149 ml of water 30 min before PCI. Intracoronary electrocardiogram was continuously monitored to assess the greatest ST-segment elevation or depression from baseline. In placebo-treated patients, the change of ST-segment shift during the second inflation was significantly smaller than that during the first inflation (19.3 +/- 9.1 vs. 15.7 +/- 8.7, p = 0.005). In contrast, in gin-treated patients, the change of ST-segment shift during the second inflation was significantly greater than that during the first inflation (18.7 +/- 7.2 vs. 22 +/- 10, p = 0.03). The group-inflation interaction for ST-segme...Continue Reading

References

Feb 1, 1988·Pain·Kenneth M Woodrow, Lorne G Eltherington
Mar 1, 1994·Angiology·H OdaF Numano
Sep 19, 2003·Journal of the American College of Cardiology·Warren K Laskey, Dana Beach
Dec 21, 2005·Circulation·Kenneth J MukamalMurray A Mittleman
Apr 17, 2007·Journal of the American College of Cardiology·Massoud A LeesarRoberto Bolli

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Citations

Sep 15, 2010·European Heart Journal·Giampaolo NiccoliAdrian P Banning
Jan 7, 2009·Therapeutic Advances in Cardiovascular Disease·Eric N ChurchillDaria Mochly-Rosen
Feb 4, 2010·Internal and Emergency Medicine·Augusto Di CastelnuovoGiovanni de Gaetano
Feb 18, 2012·International Journal of Cardiology·Rajesh Movva, Vincent M Figueredo
Dec 10, 2015·Sports Medicine·Anthony V IncognitoPhilip J Millar
Jan 15, 2009·Journal of Interventional Cardiology·Andy S C YongLeonard Kritharides
Jul 19, 2011·Alcoholism, Clinical and Experimental Research·Matteo CameliSergio Mondillo
Jun 24, 2015·Nature Reviews. Cardiology·Joaquim Fernández-Solà
Sep 14, 2015·European Heart Journal·Giampaolo NiccoliFilippo Crea
Nov 17, 2009·Journal of Molecular and Cellular Cardiology·Grant R BudasDaria Mochly-Rosen
Nov 2, 2011·Journal of Molecular and Cellular Cardiology·Maike Krenz, Ronald J Korthuis
Jul 18, 2009·Journal of the American College of Cardiology·Giampaolo NiccoliFilippo Crea
Apr 14, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Jason N Peart, John P Headrick
Jul 4, 2019·Circulation Research·Giampaolo NiccoliIngo Eitel
May 23, 2013·Journal of Cardiovascular Medicine·Pasquale PagliaroClaudia Penna
Nov 13, 2008·Journal of Cardiovascular Medicine·Italo PortoFilippo Crea
Aug 12, 2010·Acute Cardiac Care·Giampaolo NiccoliFilippo Crea
Apr 17, 2021·BMC Cardiovascular Disorders·Zahra JalaliAli Esmaeili Nadimi

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