PMID: 6579537Nov 1, 1983Paper

Ethanol acceptance as a function of genotype amounts of brain [Met]enkephalin

Proceedings of the National Academy of Sciences of the United States of America
K BlumJ E Wallace


Our results indicate a negative correlation between the amount of ethanol (10%) consumed and endogenous levels of brain [Met]enkephalin in C57BL/6J (alcohol-preferring) and DBA/2J (alcohol-nonpreferring) inbred mice strains. Additionally, it was found that 8 wk after 1-day starved groups of both C57BL/6J and DBA/2J mice were challenged with ethanol (10%) for 1-day acceptance, they had significantly lower levels of brain [Met]enkephalin compared with their nonalcohol-treated controls. These results suggest that the brain endogenous peptidyl opiates may play a crucial role in alcohol-seeking behavior.


Jan 1, 1976·Annals of the New York Academy of Sciences·A K Ho, R C Chen
Feb 1, 1982·The Journal of Pharmacy and Pharmacology·A K Ho, N Rossi
May 1, 1982·Pharmacology, Biochemistry, and Behavior·R D Myers, E C Critcher
Sep 1, 1982·The Journal of Clinical Endocrinology and Metabolism·A R GenazzaniF Savoldi
Jan 1, 1983·Alcoholism, Clinical and Experimental Research·A S LevineJ E Morley


Jan 1, 1991·Psychopharmacology·J C FroehlichT K Li
Jan 1, 1988·Journal of Substance Abuse Treatment·J Wallace
Dec 3, 1999·Progress in Neuro-psychopharmacology & Biological Psychiatry·M S Cowen, Andrew John Lawrence
Jun 5, 2002·Neuroscience Letters·Heather N Koenig, M Foster Olive
Jul 1, 1988·Journal of Psychoactive Drugs·K Blum, M C Trachtenberg
Oct 31, 1994·Annals of the New York Academy of Sciences·W A Banks, A J Kastin
May 15, 1989·Experientia·K BlumM C Trachtenberg
May 15, 1989·Experientia·M E Charness
May 1, 1994·The International Journal of Neuroscience·F J Lichtigfeld, M A Gillman
May 29, 2004·Alcoholism, Clinical and Experimental Research·W A BanksJohn E Morley
Jan 1, 1987·The American Journal of Drug and Alcohol Abuse·M C Trachtenberg, K Blum
Apr 1, 2006·Alcoholism, Clinical and Experimental Research·Jennifer Lynn ShortAndrew John Lawrence
Aug 1, 1988·The International Journal of the Addictions·K Blum, M C Trachtenberg
Feb 20, 1998·Appetite·M E Mercer, M D Holder

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