Ethanol acutely inhibits ionotropic glutamate receptor-mediated responses and long-term potentiation in the developing CA1 hippocampus.

Alcoholism, Clinical and Experimental Research
Michael P Puglia, Carlos Fernando Valenzuela

Abstract

Developmental ethanol (EtOH) exposure damages the hippocampus, causing long-lasting alterations in learning and memory. Alterations in glutamatergic synaptic transmission and plasticity may play a role in the mechanism of action of EtOH. This signaling is fundamental for synaptogenesis, which occurs during the third trimester of human pregnancy (first 12 days of life in rats). Acute coronal brain slices were prepared from 7- to 9-day-old rats. Extracellular and patch-clamp electrophysiological recording techniques were used to characterize the acute effects of EtOH on alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptor (AMPAR)- and N-methyl-D-aspartate receptor (NMDAR)-mediated responses and long-term potentiation (LTP) in the CA1 hippocampal region. Ethanol (40 and 80 mM) inhibited AMPAR- and NMDAR-mediated field excitatory postsynaptic potentials (fEPSPs). EtOH (80 mM) also reduced AMPAR-mediated fEPSPs in the presence of an inhibitor of Ca2+ permeable AMPARs. The effect of 80 mM EtOH on NMDAR-mediated fEPSPs was significantly greater in the presence of Mg2+. EtOH (80 mM) neither affected the paired-pulse ratio of AMPAR-mediated fEPSPs nor the presynaptic volley. The paired-pulse ratio of AMPAR-mediated excitatory...Continue Reading

References

Mar 31, 1989·Science·D M LovingerF F Weight
Sep 1, 1981·Canadian Journal of Physiology and Pharmacology·D DurandP L Carlen
Apr 1, 1995·Alcoholism, Clinical and Experimental Research·H S SwartzwelderM I Tayyeb
Oct 1, 1995·Alcoholism, Clinical and Experimental Research·D MartinH S Swartzwelder
May 6, 1998·Current Opinion in Neurobiology·M Constantine-Paton, H T Cline
Jun 1, 2000·Alcoholism, Clinical and Experimental Research·E T CostaC F Valenzuela
Sep 16, 2000·The Journal of Biological Chemistry·E T CostaC F Valenzuela
Oct 13, 2001·Brain Research. Molecular Brain Research·J Schummers, M D Browning
Feb 1, 2002·Alcoholism, Clinical and Experimental Research·Timothy B Johnson, Charles R Goodlett
Feb 5, 2002·Annual Review of Physiology·Robert S Zucker, Wade G Regehr
Feb 13, 2002·Alcohol·J A Mennella, P L Garcia-Gomez
Apr 17, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Elek MolnarJoshua K Duckworth
Dec 7, 2002·Nature Neuroscience·Hiroki YasudaRobert C Malenka
Apr 16, 2003·Brain Research. Developmental Brain Research·Shu-Huei Hsiao, Gerald D Frye
Apr 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Natasa SavićR Anne McKinney
May 7, 2003·Proceedings of the National Academy of Sciences of the United States of America·Mario CartaC Fernando Valenzuela
Oct 24, 2003·Alcoholism, Clinical and Experimental Research·O J AriwodolaJ L Weiner
Dec 11, 2003·JAMA : the Journal of the American Medical Association·Robert J SokolBeth Nordstrom
Jan 7, 2004·Journal of Physiology, Paris·Xavier Leinekugel
Jan 28, 2004·Alcoholism, Clinical and Experimental Research·Regina E MaldveRichard A Morrisett
Feb 20, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marisa RobertoGeorge R Siggins

❮ Previous
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Citations

Feb 26, 2016·Neuroscience and Biobehavioral Reviews·Christine J FontaineBrian R Christie
Dec 4, 2015·Behavioural Brain Research·Anna R PattenBrian R Christie
May 4, 2012·Alcoholism, Clinical and Experimental Research·Devesh MishraKarima Chergui
Mar 21, 2012·Basic & Clinical Pharmacology & Toxicology·Tommi Möykkynen, Esa R Korpi
Apr 11, 2012·Alcoholism, Clinical and Experimental Research·Richard LiebermanJonathan Covault
Jun 8, 2011·Behavioural Brain Research·Sara KostFiona E Parkinson
Mar 26, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·K E BoschenA Y Klintsova
Aug 13, 2013·Behavioural Brain Research·S A JablonskiM E Stanton
Jun 22, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ewa Jakubowska-DogruSinan Yürüker
Jul 1, 2014·Reviews in the Neurosciences·Ioannis BakoyiannisDespina Perrea
Mar 1, 2011·Alcoholism, Clinical and Experimental Research·Nathen J Murawski, Mark E Stanton
Aug 18, 2018·Learning & Memory·David M Lovinger, Karina P Abrahao
Jun 26, 2015·Alcoholism, Clinical and Experimental Research·Crystal L LantzAlexandre E Medina
Jul 5, 2017·Frontiers in Synaptic Neuroscience·Elissa L WongAnia K Majewska
Sep 26, 2020·Neuroscience and Biobehavioral Reviews·Stefania CiafrèMarco Fiore
Jan 23, 2021·Neurobiology of Learning and Memory·Mark E StantonNicholas A Heroux

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