Ethanol: an enhancer of transplantation antigen expression.

Alcoholism, Clinical and Experimental Research
D S SingerM A Kolber

Abstract

Major histocompatibility antigens (MHC) play a pivotal role in the immune response. Abnormal expression of MHC antigens has been correlated with aberrant regulation of the immune response. Studies on the effect of ethanol on class I MHC antigens demonstrate that ethanol significantly enhances their cell surface expression in a variety of cell lines in vitro. These changes in cell surface levels reflect increased intracellular protein synthesis and increased steady state mRNA levels. The effective ethanol concentrations (0.1-1.0%) are physiologically attainable. Measurement of class I MHC antigens on peripheral blood lymphocytes in a population of acutely ethanol-intoxicated patients showed a highly significant increase relative to controls. The possibility that the elevated levels of MHC antigens induced by ethanol may play a role in the evolution of ethanol-related disease is discussed.

References

Oct 1, 1986·Cellular Immunology·D R Kaplan
Jan 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T CollinsJ S Pober
Dec 1, 1987·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·L J ParentD S Singer
May 1, 1983·Molecular and Cellular Biology·D S SingerS Rudikoff
Apr 1, 1984·Liver·T PorallaK H Meyer zum Büschenfelde

❮ Previous
Next ❯

Citations

Sep 1, 1991·Journal of Clinical Immunology·R T CookM Noel
Mar 1, 1992·Brain, Behavior, and Immunity·R YirmiyaA N Taylor
Jun 13, 1998·Journal of Hepatology·F J LasoA Orfao
Sep 25, 1999·Clinics in Dermatology·A D Cohen, S Halevy
Dec 1, 1996·Alcoholism, Clinical and Experimental Research·F J LasoA Orfao
Feb 1, 1997·Alcoholism, Clinical and Experimental Research·P K Giberson, J Weinberg
Aug 1, 1991·Alcoholism, Clinical and Experimental Research·B RuhlandC M Peterson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.