PMID: 6403959Jan 1, 1983Paper

Ethanol and behavioral variability in the radial-arm maze

Psychopharmacology
L D Devenport, V J Merriman

Abstract

Ethanol (0.75, 1.5, 2.0 g/kg ethyl alcohol) consistently and profoundly narrowed three independent dimensions of behavioral variability (BV) exhibited by rats in an eight-arm radial maze. Thie was true for all doses except the lowest. Rats were run with a replacement procedure wherein rewards (two food pellets) were replaced after they were taken. With no constraints against where, how, or by what route rewards could be taken, the three indices of spontaneous BV recorded were the number of different arms chosen, the sequence of visitation, and instances of deviations from goal-directed activity. The behavior of saline and low-dose groups was widely variable in form and place; and the sequence of behavior was relatively unpredictable from trial to trial and from session to session. Medium and high doses of ethanol exerted a marked organizing influence on behavior. Superfluous topographies were eliminated, sequences became highly, and in many cases perfectly predictable, and spatial BV declined. The considerable promotion of stereotypy by ethanol helps to explain many effects of the drug, e.g., how the drug can in some instances impair, and in others facilitate performance. We propose that the scores from tasks whose mastery enta...Continue Reading

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Citations

Jan 1, 1989·Psychopharmacology·L D Devenport, R L Hale
Jan 1, 1990·Psychopharmacology·E McElroy, A Neuringer
Oct 1, 1985·Experimental Neurology·E J KasarskisC J Frederickson
Jan 1, 1987·Physiology & Behavior·D S Olton
Feb 1, 1986·Pharmacology, Biochemistry, and Behavior·D J McCann, J C Winter
Oct 1, 1986·Pharmacology, Biochemistry, and Behavior·D M Maier, L A Pohorecky
Oct 1, 1986·Pharmacology, Biochemistry, and Behavior·P Willner, K A Birbeck
Jun 1, 1986·Pharmacology, Biochemistry, and Behavior·K F MeliaG F Koob
Jul 1, 1989·Pharmacology, Biochemistry, and Behavior·K F Melia, C L Ehlers
Nov 1, 1987·Alcohol·D M Maier, L A Pohorecky
Jul 1, 1988·Neurotoxicology and Teratology·M AkaikeT Sakaguchi
Jan 1, 1986·Behavioral and Neural Biology·L D Devenport, N Cater
May 19, 2006·The Quarterly Journal of Experimental Psychology : QJEP·Mary C Olmstead
Jun 1, 1995·Alcoholism, Clinical and Experimental Research·B Givens
Dec 3, 2008·The Journal of the Acoustical Society of America·Rüdiger RieschFrank Thomsen
Apr 1, 1989·Psychological Reports·P J McKinleyL T Crow
Jan 18, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Yolanda García-RebolloNúria Ferré
Jan 1, 1988·Neuroscience and Biobehavioral Reviews·E D Levin
Aug 30, 2006·Alcohol·Ratna Sircar, Debashish Sircar
Dec 29, 2006·Journal of the Experimental Analysis of Behavior·Ryan D WardAmy L Odum
Jul 1, 1990·Journal of the Experimental Analysis of Behavior·L CohenD Rhodes

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