Ethanol and cocaine intake by rats selectively bred for oral opioid acceptance

Pharmacology, Biochemistry, and Behavior
K R Carlson, L Perez

Abstract

Lines which accept or reject the potent opioid etonitazene, and a randomly bred control line, were assessed for the specificity of selective breeding. Drug-naive subjects from generation 8 were offered a continuous choice between water and 10% ethanol for 20 days. There was no difference between the accepting and rejecting lines in preference for one fluid, or in amount of ethanol consumed. The same rats were then given a choice between water and increasing concentrations (0.08-0.64 mg/ml) of cocaine, 7 days at each concentration. There were no differences among the lines in preference for the drug, but the rejecting line drank more of the cocaine solution than the accepting line. Finally, these rats were subjected to the regimen used in choosing rats for selective breeding, 4 days of a water-etonitazene choice. In their preference for etonitazene the order of the lines was as expected: accepting > control > rejecting. In addition, the accepting line drank more of the etonitazene solution than the other two lines. These data suggest that selection has been rather specific and not for a generalized tendency to become intoxicated.

References

Jan 1, 1979·Pharmacology, Biochemistry, and Behavior·M E Carroll, R A Meisch
Jan 1, 1975·European Journal of Pharmacology·A BarnettR Taber
Feb 1, 1977·Pharmacology, Biochemistry, and Behavior·L A DykstraD E McMillan
Aug 1, 1992·Pharmacology, Biochemistry, and Behavior·T SuzukiR A Meisch
Jun 24, 1992·European Journal of Pharmacology·M SalaE Gori
May 1, 1992·Trends in Pharmacological Sciences·J C Crabbe, J K Belknap
Apr 1, 1991·Pharmacology, Biochemistry, and Behavior·F R GeorgeS R Goldberg
Oct 1, 1989·Pharmacology, Biochemistry, and Behavior·K R Carlson
Feb 1, 1989·Trends in Pharmacological Sciences·F R George, S R Goldberg
Sep 1, 1987·Pharmacology, Biochemistry, and Behavior·G J GattoT K Li
Jan 1, 1993·Psychopharmacology·P Hyyatiä, J D Sinclair
Jan 1, 1993·Life Sciences·M S MooltenK R Carlson
Mar 1, 1993·Behavior Genetics·T K LiD P Doolittle
May 1, 1993·Progress in Neuro-psychopharmacology & Biological Psychiatry·F R George
Apr 1, 1996·Pharmacology, Biochemistry, and Behavior·K R CarlsonM S Moolten

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Citations

Mar 27, 2001·Pharmacology, Biochemistry, and Behavior·M F StrombergS L Dewey
Jan 8, 1999·Peptides·G A OlsonA J Kastin
Feb 13, 2001·Drug and Alcohol Dependence·R W PickensA Umbricht
Nov 21, 2008·Behavioural Pharmacology·Shuangteng HeKenneth Grasing
Aug 8, 2008·Basic & Clinical Pharmacology & Toxicology·Anne TammimäkiPekka T Männistö
Feb 18, 2015·Pharmacology, Biochemistry, and Behavior·Tanseli NesilSakire Pogun

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