PMID: 9523563Apr 2, 1998Paper

Ethanol and regulation of the NMDA receptor subunits in fetal cortical neurons

Journal of Neurochemistry
M Kumari, Maharaj K Ticku

Abstract

Previous studies have shown that chronic ethanol treatment up-regulates the expression of the N-methyl-D-aspartate (NMDA) receptor number and function both in vitro and in vivo. In vitro chronic ethanol treatment specifically augments mRNA levels of the R2B subunit without altering R1 subunit mRNA levels, although similar treatment results in increased levels of both R1 and R2B polypeptides. To further delineate the molecular mechanisms involved in differential regulation of NMDA receptor subunits by chronic ethanol treatment (50 mM, 5 days), we have determined the mRNA stability of the NMDA R1 and R2B subunits and the transcription rate of the respective genes using mouse fetal cortical neurons. Our observations demonstrated that ethanol stabilized the NMDA R1 mRNA over the time period examined (24 h) without altering the stability of the R2B mRNA. Chronic exposure of fetal cortical neurons to ethanol enhanced the rate of R2B gene transcription approximately twofold. Taken together, these results suggest that up-regulation of the NMDA receptor number seen in cultured cortical neurons after chronic ethanol treatment is due to the regulation of the NMDA R2B receptor subunit at the transcriptional level and that of the NMDA R1 su...Continue Reading

Citations

May 5, 1999·Current Opinion in Neurology·D M Ferriero, D A Dempsey
Jul 24, 2004·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Dorit Ron
Jan 7, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·D RujescuA Szegedi
Jan 12, 2016·Biomolecules·Antje Anji, Meena Kumari
Jul 11, 2003·Annals of the New York Academy of Sciences·Antje AnjiMeena Kumari
Jul 11, 2003·Annals of the New York Academy of Sciences·Meena KumariMaharaj K Ticku
Feb 1, 2007·Journal of Applied Toxicology : JAT·William SlikkerCheng Wang
Jul 10, 2010·International Journal of Environmental Research and Public Health·John C M Brust
Dec 9, 1998·Journal of Biomedical Science·G Tsai
Feb 28, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Cheng WangWilliam Slikker
May 19, 2006·The European Journal of Neuroscience·Antje Anji, Meena Kumari
Jul 5, 2003·The Journal of Biological Chemistry·Sajida HassanMichael F Miles
Apr 29, 1999·Journal of Neuroscience Research·C WangK M Johnson
Feb 9, 2000·Frontiers in Neuroendocrinology·N A Compagnone, S H Mellon
May 23, 2001·Progress in Neurobiology·N C Danbolt
Aug 1, 1998·Brain Research. Molecular Brain Research·H S KalluriM K Ticku
Jun 29, 2000·Neurochemistry International·P R DoddP A Wilce
May 31, 2002·Brain Research. Developmental Brain Research·Frederick P BellingerPeter A Wilce
Feb 19, 2004·Brain Research. Molecular Brain Research·C R Marutha Ravindran, Maharaj K Ticku
May 3, 2005·Neuroscience Letters·C R Marutha Ravindran, Maharaj K Ticku
Jul 13, 2005·Brain Research·Juan Manuel MalerJohannes Kornhuber
Sep 29, 2009·Pharmacology & Therapeutics·Leonardo PignataroNeil L Harrison

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.