Ethanol and water extract of purple sweet potato exhibits anti-atherosclerotic activity and inhibits protein glycation

Journal of Medicinal Food
Ki-Hoon ParkKyung-Hyun Cho

Abstract

It is well known that extracts of purple sweet potato (PSP) have potent antioxidant activity. However, it has not been established whether extracts of PSP inhibit oxidation of low-density lipoprotein (LDL) or protein glycation. LDL oxidation and protein glycation are well-known risk factors for chronic metabolic diseases, such as atherosclerosis and diabetes mellitus. Chopped and sliced PSP and yellow sweet potato (YSP) were extracted individually at a concentration of 1 g of PSP tuber/mL using either ethanol or water for 6 hours. The PSP ethanol extract (100-fold diluted) showed stronger radical (2,2-diphenyl-1-picrylhydrazyl radical) scavenging activity than the water extract of PSP and the ethanol extract of YSP (up to a sixfold higher activity). The ethanol extract of PSP also exhibited the highest increase in ferric reducing ability among all extracts. Cupric ion-mediated LDL oxidation was strongly inhibited by the ethanol extract of PSP, with similar potency to vitamin C treatment (final concentration, 10 mM). The PSP extract strongly inhibited fructose-mediated protein glycation as determined by fluorescence spectroscopy. The PSP extract-treated apolipoprotein (apo) A-I showed a decreased multimerization pattern on sodiu...Continue Reading

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Citations

Jul 15, 2015·The Journal of Nutritional Biochemistry·Chunhui SunYuanlin Zheng
Jan 10, 2012·Journal of the Science of Food and Agriculture·Jayanta M SankhariA V Ramachandran
Mar 14, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Tyler GarnerBradley S Fleenor
Dec 20, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yan-Tao HanLe-Xin Wang
Sep 4, 2013·The Cochrane Database of Systematic Reviews·Cheow Peng Ooi, Seng Cheong Loke
Nov 14, 2013·Journal of Agricultural and Food Chemistry·Chen-Chung LiaoChia-Feng Kuo

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Methods Mentioned

BETA
electrophoresis
column chromatography
glycosylation
MDA

Software Mentioned

SPSS

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