PMID: 9450501Feb 5, 1998Paper

Ethanol blocks the central action of IGF-1 to induce luteinizing hormone secretion in the prepubertal female rat

Life Sciences
J K HineyW L Dees

Abstract

Insulin-like growth factor-1 (IGF-1) is emerging as a signal of peripheral origin capable of acting centrally to induce luteinizing hormone (LH) secretion and accelerate the initiation of female puberty. Since we have shown previously that ethanol (ETOH) can suppress prepubertal LH release and delay female puberty, we hypothesized that these detrimental effects might be due, at least in part, to the drugs ability to alter the central actions of IGF-1. Thus, we have investigated the effects of ETOH on IGF-1 induced LH release in vivo, and on IGF-1 induced prostaglandin-E2 (PGE2) and LH-releasing hormone (LHRH) release in vitro from rats during the juvenile phase of development as well as from rats during the early stage of first proestrus. For the in vivo experiment three initial jugular blood samples were taken at 10-min. intervals from all rats, then the animals received either a 3g/Kg dose of ETOH or an equal volume of saline by gastric gavage. The rats were subsequently left undisturbed for 90 min. to allow time for ETOH absorption, then a single blood sample was drawn from each rat. Finally, IGF-1 (200 ng/3 microl) was microinjected into the third ventricle of all animals and five more blood samples were withdrawn at 10 min...Continue Reading

References

Jan 1, 1990·Neuroendocrinology·W L Dees, C W Skelley
Oct 1, 1990·Domestic Animal Endocrinology·C A RobertsB H Breier
Jun 1, 1985·The Journal of Clinical Endocrinology and Metabolism·K C CopelandA Bartke
Apr 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·J Antunes-Rodrigues, S M McCann
Dec 1, 1982·The Journal of Clinical Endocrinology and Metabolism·K C CopelandV D Castracane
Oct 1, 1993·The Journal of Endocrinology·B A CrawfordD J Handelsman

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Citations

Mar 16, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jill K HineyWilliam Les Dees
Mar 9, 1999·Alcoholism, Clinical and Experimental Research·V K SrivastavaW L Dees
Aug 16, 2001·Alcoholism, Clinical and Experimental Research·N V EmanueleM A Emanuele
Apr 25, 2018·Alcoholism, Clinical and Experimental Research·Vinod K SrivastavaWilliam L Dees
Sep 2, 2009·Alcoholism, Clinical and Experimental Research·W Les DeesJill K Hiney
Oct 21, 2016·Alcoholism, Clinical and Experimental Research·Joanna Helena SliwowskaJoanne Weinberg

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