Ethanol differentially affects metabolic and mitotic processes in chick embryonic cells

Alcoholism, Clinical and Experimental Research
I A ShibleyS Pennington

Abstract

Our laboratory has been investigating the mechanisms by which ethanol-induced growth inhibition occurs in a developing embryo, and our studies have focused on disruption of cellular signaling pathways. Previous work on ethanol-induced changes in signaling systems that regulate ornithine decarboxylase activity indicated that the pathways containing protein kinase A, protein kinase C (PKC), and insulin-dependent tyrosine kinase were important for the control of ornithine decarboxylase in chick embryonic cells. Herein, we report ethanol's effect on the regulation of glucose uptake and thymidine uptake by these same kinase pathways. A pronounced increase in glucose uptake was associated with PKC downregulation in both vehicle- and ethanol-exposed cells, with the larger increase occurring in ethanol-exposed cells. An increase in thymidine uptake was associated with an activation of all three kinases, as well as with downregulation of PKC. Because previous work on signaling pathways has looked for changes in the insulin signaling pathway, the work herein focuses on the signaling pathways involving protein kinase A and PKC. cAMP levels were increased by ethanol treatment, but the increase was relatively small. Analysis of changes in P...Continue Reading

References

Dec 1, 1990·Alcoholism, Clinical and Experimental Research·S N Pennington
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J BurtonT A Waldmann
Aug 1, 1990·Biochemical Pharmacology·C S RabeB Tabakoff
Jan 1, 1990·Life Sciences·S Skwish, W Shain
Feb 1, 1989·Trends in Biochemical Sciences·J E DumontP P Roger
May 1, 1989·Neurotoxicology and Teratology·S P SinghG L Pullen
Nov 30, 1987·Drug and Alcohol Dependence·S Pennington, G Kalmus
Feb 1, 1988·Alcoholism, Clinical and Experimental Research·S Pennington
Jan 1, 1988·Advances in Alcohol & Substance Abuse·P ValveriusB Tabakoff
Oct 10, 1986·Science·E Rozengurt
Mar 1, 1988·Alcohol·S N Pennington
Jan 1, 1986·Methods in Enzymology·R M BellC Loomis
Mar 1, 1986·Alcoholism, Clinical and Experimental Research·A K SnyderG L Pullen
Sep 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·A G Gilman
Jul 1, 1984·Alcoholism, Clinical and Experimental Research·J W BoydS N Pennington
Apr 22, 1983·European Journal of Pharmacology·A ShenR G Thurman
May 1, 1984·Alcoholism, Clinical and Experimental Research·S N PenningtonG W Kalmus
Dec 1, 1982·Endocrinology·F De PabloR M Pruss
Jun 1, 1995·Alcoholism, Clinical and Experimental Research·S N PenningtonJ L Morgan
Jan 1, 1995·Biology of the Neonate·I A Shibley, S N Pennington
Feb 1, 1994·European Journal of Biochemistry·M Mueckler
Nov 1, 1993·Cellular Signalling·N W MerrallG W Gould
Jan 31, 1994·Neuroscience Letters·J D YinglingB A Jackson
May 15, 1993·Analytical Biochemistry·T W Briers, C Desmaretz

❮ Previous
Next ❯

Citations

Nov 24, 1999·Brain Research. Developmental Brain Research·T A McIntyreI A Shibley
Oct 8, 1999·Alcoholism, Clinical and Experimental Research·C D Stubbs, S J Slater
Nov 16, 2004·Toxicology and Applied Pharmacology·Christopher J BorgertAnn M Mason
May 20, 1999·Annual Review of Pharmacology and Toxicology·R C Baker, R E Kramer
Oct 13, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·George R Flentke, Susan M Smith
Sep 25, 1999·Clinics in Dermatology·R WolfV Ruocco
Jun 3, 2021·International Journal of Molecular Sciences·Zita Szentkereszty-KovácsDániel Törőcsik

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.